Systemic Lupus Erythematosus

Description

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.

Lupus is the prototypic autoimmune disease and Systemic Lupus Erythematosus examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

Key Features

•Highly illustrated and in full color throughout

•Basic science section expanded, allowing the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment

•Clinical aspects and new drugs are covered in great detail providing a useful reference to professionals interested in lupus

Readership

Basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists. Residents and fellows in training, as well as primary internists with an interest in the disease and medical libraries.

Quotes

Published Review of Fourth Edition
"The editor's purpose is to provide the reader with the latest information about SLE, its science, presentation, and treatment.This edition of Systemic Lupus Erythematosus continues to be an up-to-date, comprehensive, and well-referenced resource for both the basic science and clinical medicine aspects of this complex disease. The book takes us on a journey starting with the disease pathogenesis, continuing with animal models of lupus, various autoantibodies and antigens, the clinical approach to diagnosis and the affected organs and tissues, and ending with current therapies. It will be an excellent reference book for students of immunology/rheumatology and for experienced research scientists and clinicians. Reflecting the emerging information in this dynamic field, the volume includes new chapters on fibromyalgia and osteoporosis in association with SLE, and enhanced chapters on the molecular aspects of the cellular immunology of SLE, the neuropsychiatric aspects of SLE, and the various aspects of antiphospholipid syndrome. The addition of a searchable CD-ROM makes it easier to identify the updated information and to download the images for educational purposes. The chapters are written by experts in their respective fields, and each chapter independently represents a piece of the lupus puzzle. As Dr Lahita states in the introduction, "Reading the chapters in this book will not solve the mystery, but it will give you the impression that we are close to understanding the illness."
-Rheumatology, 2004

Published Review of Third Edition:
"This book successfully links basic science with clinical medicine, providing a framework within which to understand this complex disease. As Lahita states in the introduction, 'The history of discovery is now in the log phase of growth.' The third edition of Systemic Lupus Erythematosus conveys the excitement and the breadth of this dynamic field. This volume will be an excellent resource for basic and clinical scientists, as well as for the students of imunology and rheumatology. The chapters are well-referenced and can be read independently- as befits a reference book."
-Jane E. Salmon, Weill Medical College, Cornell University, New York, USA (March 2000)

Table of Contents

Section I: Basis of Disease Pathogenesis

A. Genetics

• 1 Major histocompatibility complex class II
  Michelle M.A. Fernando and Timothy J. Vyse
• 2 Genetic susceptibility and class III complement genes
  John P. Atkinson, Peter M. Schneider and C. Yung Yu
• 3 Constitutive genes and lupus
  Betty P. Tsao and Yun Deng
• 4 Genetics of lupus in mice
  Dwight H. Kono and Argyrios N. Theofilopoulos

B. Cellular Pathogenesis

• 5 Tolerance and autoimmunity
  Shiv Pillai and Kendra N. Taylor
• 6 Dendritic cells in SLE
  Gerlinde Obermoser, Karolina Palucka, Hideki Ueno, Jacques Banchereau, and Virginia Pascual
• 7 T cells and systemic lupus erthematosus
  Jose C. Crispin and George C. Tsokos
• 8 B-lymphocyte biology in SLE
  Mark J. Mamula
• 9 Polymorhonuclear and endothelial cells
  Robert Clancy
• 10 Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T cells of patients with SLE
  Andras Perl
• 11 Cell cycle regulation and systemic lupus erythematosus
  Dimitrios Balomenos
• 12 The role of reactive nitrogen and oxygen intermediates in systemic lupus erythematosus
  Ahmad K. Mashmoushi, Gary S. Gilkeson and Jim C. Oates

C. Humoral Pathogenesis

• 13 Origins of antinuclear antibodies
  Westley H. Reeves, Yuan Xu, Haoyang Zhuang, Yi Li and Lijun Yang
• 14 Anti-DNA antibodies: Structure, regulation and pathogenicity
  Cynthia Aranow, Dun Zhou and Betty Diamond
• 15 Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis
  Mary Keogan, Grainne Kearns and Caroline A. Jefferies
• 16 Antihistone and antispliceosomal antibodies
  Minoru Satoh, Marvin J. Fritzler, and Edward K.L. Chan
• 17 Toll-like receptors in SLE
  Terry K. Means
• 18 Interferon-alpha in systemic lupus erythematosus
  Mary K. Crow
• 19 Immune complexes in systemic lupus erythematosus
  Mark H. Wener
• 20 Complement and tissue injury in SLE
  Chau-Ching Liu and Joseph Ahearn
• 21 Humoral pathogenesis: Fc receptors in autoimmunity and end-organ damage
  T. Ernandez and T.N. Mayadas

D. Environmental Aspects of Pathogenesis

• 22 Drug-induced lupus mechanisms
  Raymond L. Yung and Bruce C. Richardson
• 23 Gender and age in lupus
  Robert G. Lahita
• 24 Roles for infections in systemic lupus erythematosus pathogenesis
  Evan S. Vista, A. Darise Farris and Judith A. James
• 25 Systemic lupus erythematosus in domestic animals
  Michael J. Day

E. Mechanisms of Tissue Injury

• 26 Pathogenesis of lupus nephritis
  Yong Du and Chandra Mohan
• 27 Tissue injury and the skin
  Annegret Kuhn, Markus Bohm and Thomas A. Luger
• 28 Neuropsychiatric systemic lupus erythematosus: Mechanisms of injury
  Meggan Mackay, Aziz M. Ulug and Bruce T. Volpe
• 29 Atherosclerosis and tissue injury in systemic lupus erythematosus
  Ingrid Avalos and C. Michael Stein

Section II: Clinical Aspects of Disease

A. Clinical Presentation

• 30 The clinical presentation of systemic lupus erythematosus
  Robert G. Lahita
• 31 Neonatal lupus
  Jill P. Buyon and Deborah M. Friedman
• 32 SLE in children
  Rina Mina and Hermine I. Brunner
• 33 Drug-induced disease
  Anne-Barbara Mongey and Evelyn V. Hess
• 34 Laboratory evaluation of patients with systemic lupus erythematosus
  Peter H. Schur
• 35 Pregnancy and reproductive concerns in systemic lupus erythematosus
  Carl Laskin, Karen Spitzer and Christine A. Clark
• 36 Epidemiology of systemic lupus erythematosus
  Catia Duarte, Maura Couto, Luis Ines and Matthew H. Liang
• 37 Monitoring disease activity
  Kenneth C. Kalunian and Joan T. Merrill
• 38 Incomplete lupus erythematosus
  Johannes C. Nossent and Tom J.G. Swaak
• 39 Design of clinical trials for SLE
  Joan T. Merrill, Ken Kalunian and Jill P. Buyon

B. Organ Systems

• 40 The nervous system and lupus
  John G. Hanly
• 41 Skin
  Victoria P. Werth, Cristian Vera-Kellet and Jan P. Dutz
• 42 Kidney
  Brad H. Rovin and Isaac E. Stillman
• 43 Heart
  Kathleen Macsimowicz-McKinnon and Susan Manzi
• 44 Vasculitis
  Barri Fessler and Gary S. Hoffman
• 45 Lung
  Aryeh Fischer and Roland M. du Bois
• 46 Gastrointestinal: Liver
  Ian R. Mackay
• 47 Gastrointestinal: Nonhepatic
  Lloyd Mayer
• 48 Cellular hematology
  Seetha U. Monrad and Mariana J. Kaplan
• 49 Musculoskeletal system: Articular disease, bone metabolism
  Diane Horowitz, Galina Marder and Richard Furie

Section III: Anti-Phospholipid Syndrome

A. Pathogenesis

• 50 Antiphospholipid antibody: Pathogenesis
  Takao Koike, Tatsuya Atsumi and Olga Amengual
• 51 Endothelial cell damage and atherosclerosis
  Joan T. Merrill

B. Clinical

• 52 Laboratory testing for antiphospholipid syndrome
  Steven Krilis and Yiannia Ioannou
• 53 Clinical presentation of antiphospholipid syndrome
  Munther A. Khamashta
• 54 Pregnancy and antiphospholipid syndrome
  Kristina Milan and D. Ware Branch
• 55 Treatment of antiphospholipid syndrome
  Gerard Espinosa and Richard Cervera

Section IV: Treatment

• 56 Steroids and nonsteroidal anti-inflammatory drugs
  Olga Dvorkina and Ellen M. Ginzler
• 57 Antimalarials
  Nathalie Costedoat-Chalumeau, Gaelle Leroux, Jean-Charles Piette and Zahir Amoura
• 58 Cytotoxic agents
  Eva D. Papadimitraki, George Bertsias, George Chamilos and Dimitrios T. Boumpas
• 59 Biological agents
  Vasileios C. Kyttaris

Author Information

Edited by Robert G. Lahita, Chairman of Medicine and Vice President of Jersey City Medical Center, Campus of the Liberty Healthcare System Jersey City, NJ U.S.A.