Handbook of the Behavioral Neurobiology of Serotonin, Vol. 18

Description

Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.

The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.

This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise.

The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.

Key Features

• The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system
• Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others
• The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community.
• Of great value not only for researchers and experts, but also for students and clinicians as a background reference.

Readership: neuroscientists, pharmacologists, psychiatrists, neurologists and psychologists in academia, medical institutions, pharmaceutical industry.
Level: Graduate student and up. Suited for advanced courses in behavioral genetics, behavioral pharmacology, behavioral neuroscience and psychiatry as a reference and supplementary reading material (particularly the on-line version will be useful).

Quotes

George Koob, director of the division of Psychopharmacology, Scripps Research Institute, La Jolla, Ca:
"The book has great merit in that the neurobiology of serotonin is quite extensive and has significant implications for our understanding of psychiatric disease and treatment. An update is sorely needed if it synthesizes the area by topic. The scope is comprehensive; I cannot think of anything missed. The utility would be as a reference source for research, and teaching at all levels from graduate school to medical school. Editors are outstanding scientists in the field. Choice of authors is equally outstanding. ... There is really nothing out there that pulls the world's literature on serotonin together. It is hard to get a real solid perspective on how serotonin does everything from impulsivity in suicide to depression to anxiety to mediate the effects of LSD and a tome that explains all of this would fill a niche. Readers would be graduate students, researchers, medical students, residents and university teachers."

Robert Carey, VA Medical Center, Upstate Medical University, Syracuse, NY, CA:
"There has been a major shift away from Dopamine to Serotonin so this is a very timely book proposal and the selected editors/authors are excellent choices to put together an important and successful book."

Boris Quednow, Psychiatric Hospital, University Zurich, Switzerland:
"I waited long for such a handbook of serotonin. This book was overdue for a long time and I think that it has the chance to be a bestseller in this area. The scope is indeed wide but appropriate and the utility of this book is - without any doubt - very high. The editors are highly experienced researchers in this field and the proposed authors belong to the leading scientists in serotonin research. "

Table of Contents

Section 1: Functional anatomy of the serotonergic system

• Evolution of serotonin: sunlight to suicide
  Efrain C. Azmitia
• Genetic organisation of the serotonergic system
  Ursula M. D’Souza and Ian W. Craig
• The neuronatomy of the serotonergic system
  Jean-Pierre Hornung
• Ultrastructure of the serotonin innervation in mammalian central nervous system
  Laurent Descarries Mustapha Riad and Martin Parent
• Classification and signaling characteristics of 5-HT receptors
  Joël Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin
• Distribution of 5-HT receptors in the central nervous system
  Guadalupe Mengod, Roser Cortés, M. Teresa Vilaró and Daniel Hoyer
• Measuring serotonin activity in vivo in the brains of animals and humans
  Charles A Marsden

Section 2: The neurophysiology of serotonin

• 2.1 Activity of brain serotonergic neurons in relation to physiology and behavior
  Barry L. Jacobs and Casimir A. Fornal
• 2.2 Electrophysiology of serotonin receptors
  Gerard J. Marek
• 2.3 Tryptophane hydroxylase and serotonin synthesis regulation
  Hiroyuki Hasegawa and Kazuhiro Nakamura
• 2.4 The degradation of serotonin: role of MAO
  Marco Bortolato, Kevin Chen and Jean C Shih
• 2.5 Cellular effects of serotonin in the CNS
  Rodrigo Andrade and Sheryl G. Beck
• 2.6 Serotonergic feedback control
  Trevor Sharp
• 2.7 Tryptophan depletion and serotonin release - a critical reappraisal
  Matthijs G.P. Feenstra and Geoffrey van der Plasse
• 2.8 Serotonin interaction with other transmitter systems
  Albert Adell, Analía Bortolozzi, Llorenç Díaz-Mataix, Noemí Santana, Pau Celada, and Francesc Artigas
• 2.9 Serotonergic regulation of rhythmical activity of the brain, concentrating on the hippocampus
  Robert P. Vertes
• 2.10 5-HT neurons and central CO2 chemoreception
  Carolin I. Dohle and George B. Richerson

Section 3: Serotonin and behavioural control

• 3.1 Serotonin and development
  Patricia M. Whitaker-Azmitia
• 3.2 Serotonin and basal sensory: motor control
  Robert J. Carey
• 3.3 Role of the serotonergic system in appetite and ingestion control
  Michelle D. Lee and Peter G. Clifton
• 3.4 Serotonin and sexual behavior
  Lynda Uphouse and Jutatip Guptarak
• 3.5 Serotonin in mood and emotion
  Julie G. Hensler
• 3.6 Serotonin and the neurobiology of anxious states
  Christopher A. Lowry and Matthew W. Hale
• 3.7 Role of Serotonin in Brain Reward and Regulation of Alcohol Drinking Behavior
  W. J. McBride
• 3.8 Role of central serotonin in impulsivity and compulsivity: Comparative studies in experimental animals and humans
  TW Robbins & MJ Crockett
• 3.9 Experimental studies on the role(s) of serotonin in learning and memory functions
  Jean-Christophe Cassel
• 3.10 Social behavior and serotonin
  Elif Aysimi Duman and Turhan Canli
• 3.11 Serotonin in pain and pain control
  Claudia Sommer

Section 4: Serotonin in disease conditions

• 4.1 The Impact of Stress on Serotonergic Neurotransmission
  Astrid C.E. Linthorst and Johannes M.H.M. Reul
• 4.2 Role for serotonin in depression
  Gregory V. Carr and Irwin Lucki
• 4.3 The role of serotonin in drug addiction
  Christian P. Müller, Martin E. Pum, Gunter Schumann and Joseph P. Huston
• 4.4 The serotonergic system in obsessive compulsive disorders
  Addy van Dijk, Andre Klompmakers, and Damiaan Denys
• 4.5 The role of serotonin in attention-deficit hyperactivity disorder (ADHD)
  Robert D. Oades
• 4.6 Serotonin and schizophrenia
  Boris B. Quednow, Mark A. Geyer, and Adam L. Halberstadt
• 4.7 Serotonin and serotonin receptors in hallucinogen action
  Adam L. Halberstadt and David E. Nichols
• 4.8 The role of serotonin in cortical development: implications for Autism Spectrum Disorder [ASD]
  Christine F. Hohmann and Mary E. Blue
• 4.9 Serotonin in panic and anxiety disorders
  Francisco Silveira Guimarães, Hélio Zangrossi Jr., Cristina Marta Del Ben and Frederico Guilherme Graeff
• 4.10 Serotonin and agression
  Isabel M. Quadros, Aki Takahashi and Klaus A. Miczek
• 4.11 Altered serotonin function in anorexia and bulimia nervosa
  Vikas Duvvuri, Ursula F Bailer and Walter H Kaye
• 4.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions
  Eva Friedel & Andreas Heinz
• 4.13 The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression
  Olivia F. O’Leary and John F. Cryan
• 4.14 Functional pharmacogenetics of serotonin receptors in psychiatric drug action
  Olga O. Yevtushenko, Gavin P. Reynolds

Author Information

Edited by Christian P. Muller and Barry Jacobs