Science of Pain

Description

This book presents the most current scientific understanding behind most common pain disorders. Clinical scientists involved in pain science will gain a basic understanding of the causes of many types of pain and will be able to discuss various therapies with patients. Researchers new to pain science will gain an overall understanding of pain pathophysiology and targets for pain treatments. Covering every major aspect of pain science, from molecular and cellular pathways of pain to pain disorders and their treatments, Science of Pain bridges basic and clinical research like no other book on the topic. Edited by world-renowned pain scientist and Editor-in-Chief of the journal PAIN, Allan Basbaum, this book is an in-depth reference for basic and clinical scientists in pain research who must understand the basic science of pain, and help develop new treatment strategies for pain disorders.

Key Features

• Presents the most current scientific understanding of neuroscience of pain, written by the world's leading experts
• Integrates basic neuroscience research and clinical aspects of pain disorders
• Covers both neurobiological basis and clinical treatment for a pain disorder (e.g., migraine, fibromyalgia, neuropathic pain, post-stroke pain)
• Covers pain pathways and mechanisms both in text and in full-color illustrations
• Includes topics specific to gender and age group addressing the trend in research toward developing individualized treatments

Readership

clincial neuroscientists involved in pain science; research neuroscientists involved in pain science

Contents

Preface by Basbaum and Bushnell 1 The Adequate Stimulus R.D. Treede Johannes Gutenberg-University, Mainz, Germany 2 Pain Theories F. Cervero McGill University, Montreal, QC, Canada 3 Anatomy of Nociceptors S. Mense Institut für Anatomie und Zellbiologie, Universität Heidelberg, Heidelberg, Germany 4 Molecular Biology of the Nociceptor/Transduction M.S. Gold University of Pittsburgh, Pittsburgh, PA, USA 5 Zoster-Associated Pain and Nociceptors H. Maija Helsinki University Hospital, Helsinki, Finland 6 Ectopic Generators M. Devor Hebrew University of Jerusalem, Jerusalem, Israel 7 Sodium Channels John N. Wood University College London, London, UK 8 Physiology of Nociceptors M. Ringkamp Johns Hopkins University, Baltimore, MD, USA 9 Itch E. Carstens University of California, Davis, CA, USA 10 Thermal Sensation (Cold and Heat) through Thermosensitive TRP Channel Activation Makoto Tominaga National Institutes of Natural Sciences, Okazaki, Japan 11 The Development of Nociceptive Systems G.J. Hathway University College London, London, UK 12 Appropriate/Inappropriate Developed Pain Paths J. Schouenborg Lund University, Lund, Sweden 13 Pain Control: A Child-Centered Approach Patricia A. McGrath The University of Toronto, Toronto, ON, Canada 14 Assaying Pain-Related Genes: Preclinical and Clinical Correlates V.E. Scott Global Pharmaceutical Research and Development, Abbott Park, IL, USA 15 Evolutionary Aspects of Pain E.T. Walters University of Texas at Houston, Medical School, Houston, TX, USA 16 Redheads and Pain J.S. Mogil McGill University, Montreal, QC, Canada 17 Autonomic Nervous System and Pain W. Jänig Physiologisches Institut, Christian-Albrechts-Universität zu Kiel, Germany 18 Sympathetic Blocks for Pain Sharma Columbia University, New York, NY, USA 19 Sprouting in Dorsal Root Ganglia E.M. McLachlan Prince of Wales Medical Research Institute, Randwick, NSW, Australia 20 Vagal Afferent Neurons and Pain W. Jänig Christian-Albrechts-Universität zu Kiel, Kiel, Germany 21 Sex, Gender, and Pain R.B. Fillingim University of Florida College of Dentistry, Community Dentistry and Behavioral Science Gainesville, FL, USA 22 Neurotrophins and Pain Lorne M. Mendell State University of New York, Stony Brook, NY, USA 23 Morphological and Neurochemical Organization of the Spinal Dorsal Horn A. Ribeiro-da-Silva McGill University, Montreal, QC, Canada 24 Spinal Cord Physiology of Nociception A.R. Light University of Utah, Salt Lake City, UT, USA 25 What is a Wide-Dynamic-Range Cell D. Le Bars INSERM U-713, Paris, France 26 Spinal Cord Mechanisms of Hyperalgesia and Allodynia T.J. Coderre McGill University, Montreal, QC, Canada 27 Glycine Receptors H.U. Zeilhofer University of Zurich, Zurich, Switzerland 28 Pain Following Spinal Cord Injury R.P. Yezierski Comprehensive Center for Pain Research and The McKnight Brain Institute, University of Florida, Gainesville, FL, USA 29 Long-Term Potentiation in Pain Pathways J. Sandkühler Medical University of Vienna, Vienna, Austria 30 Immune System, Pain and Analgesia H.L. Rittner Charité ? Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany 31 Mechanisms of Glial Activation after Nerve Injury L.R. Watkins University of Colorado at Boulder, Boulder, CO, USA 32 Trigeminal Mechanisms of Nociception: Peripheral and Brainstem Organization D.A. Bereiter University of Minnesota, Minneapolis, MN, USA 33 Migraine ? A Disorder Involving Trigeminal Brainstem Mechanisms P.J. Goadsby University of California, San Francisco, CA, USA 34 Tooth Pain M.R. Byers University of Washington, Seattle, WA, USA 35 Ascending Pathways: Anatomy and Physiology D. Lima Universidade do Porto, Porto, Portugal 36 Dorsal Columns and Visceral Pain W.D. Willis Jr. University of Texas Medical Branch, Galveston, TX, USA 37 Visceral Pain G.F. Gebhart University of Pittsburgh, Pittsburgh, PA, USA 38 Irritable Bowel Syndrome S. Bradesi University of California, Los Angeles, CA, USA 39 Pain in Childbirth U. Wesselmann The Johns Hopkins University School of Medicine, Baltimore, MD, USA 40 Urothelium as a Pain Organ L.A. Birder University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 41 The Brainstem and Nociceptive Modulation M.M. Heinricher Oregon Health & Science University, Portland, OR, USA 42 Emotional and Behavioral Significance of the Pain Signal and the Role of the Midbrain Periaqueductal Gray (PAG) K. Keay University of Sydney, Sydney, NSW, Australia 43 The Thalamus and Nociceptive Processing J.O. Dostrovsky University of Toronto, Toronto, ON, Canada 44 Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System S. Ohara Johns Hopkins Hospital, Baltimore, MD, USA 45 Nociceptive Processing in the Cerebral Cortex R.D. Treede Ruprecht-Karls-University Heidelberg, Heidelberg, Germany 46 Phantom Limb Pai H. Flor Central Institute of Mental Health, Mannheim, Germany 47 Human Insular Recording and Stimulation F. Mauguière Lyon I University and INSERM U879, Bron, France 48 The Rostral Agranular Insular Cortex L. Jasmin Neurosurgery and Gene Therapeutics Research Institute, Los Angeles, CA, USA 49 Descending Control Mechanisms K. Ren University of Maryland, Baltimore, MD, USA 50 Diffuse Noxious Inhibitory Controls (DNIC) D. Le Bars INSERM U-713, Paris, France 51 Fibromyalgia R. Staud University of Florida, Gainesville, FL, USA 52 Pain Perception ? Nociception during Sleep G.J. Lavigne Université de Montréal, Montreal, QC, Canada 53 Pharmacological Modulation of Pain A. Dray AstraZeneca Research and Development, Montreal, PQ, Canada 54 Forebrain Opiates J.-K. Zubieta University of Michigan, Ann Arbor, MI, USA 55 Neuropathic Pain: Basic Mechanisms (Animal) M.H. Ossipov University of Arizona, Tucson, AZ, USA 56 Animal Models and Neuropathic Pain I. Decosterd University of Lausanne, Lausanne, Switzerland 57 Neuropathic Pain: Clinical R. Baron Christian-Albrechts-Universität Kiel, Kiel, Germany 58 Neurogenic Inflammation in Complex Regional Pain Syndrome (CRPS) F. Birklein University of Mainz, Mainz, Germany 59 Complex Regional Pain Syndromes R. Baron Christian-Albrechts-Universität Kiel, Kiel, Germany 60 Poststroke Pain T.S. Jensen Aarhus University Hospital, Aarhus, Denmark 61 Psychophysics of Pain R.H. Gracely University of Michigan Health System, VAMC, Ann Arbor, MI, USA 62 Consciousness and Pain M. Devor Hebrew University of Jerusalem, Jerusalem, Israel 63 Assessing Pain in Animals S.W.G. Derbyshire University of Birmingham, Birmingham, UK 64 Psychological Modulation of Pain D.D. Price University of Florida, Gainesville, FL, USA 65 The Placebo Effect F. Benedetti University of Turin Medical School, Turin, Italy 66 Hypnotic Analgesia P. Rainville Université de Montréal, Montreal, QC, Canada INDEX

Author Information

Edited by Allan I. Basbaum, Professor and Chair, Department of Anatomy, University of California, San Francisco, USA; and M. Catherine Bushnell