Applied Clinical Pharmacokinetics

Description

The easiest and most trusted way to learn the clinical application of pharmacokinetics

The most current, hands-on book in the field, Applied Clinical Pharmacokinetics delivers clear and clinically relevant coverage of drug dosing and drug monitoring that no other text can match. Written by a nationally recognized expert, this trusted classic offers the latest standardized techniques and approaches to patient-specific dosing, plus new information on the most recent pharmacokinetically monitored drugs. All chapters have been updated and revised and include critical new references.

Applied Clinical Pharmacokinetics is logically divided into six sections:

• Basic Concepts
• Antibiotics
• Cardiovascular Agents
• Anticonvulsants
• Immunosuppressants
• Other Drugs (including Lithium and Theophylline)

Applied Clinical Pharmacokinetics includes valuable learning aids such as sample problems with answers and explanations at the end of each chapter, practical step-by-step examples of both initial dosage determinations and serum level analysis, and clear and concise summaries of essential pharmacodynamics concepts. You will also find important coverage of drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure, and patients on dialysis or other forms of renal replacement therapies.

Useful to students and practicing clinicians, Applied Clinical Pharmacokinetics is the single-best guide for understanding pharmacokinetics in real-world pharmacy practice.

Table of Contents

Part I. Basic Concepts
Chapter 1. Clinical Pharmacokinetic and Pharmacodynamic Concepts
Chapter 2. Clinical Pharmacokinetic Equations and Calculations
Chapter 3. Drug Dosing in Special Populations: Renal and Hepatic Disease, Dialysis, Heart Failure, Obesity, and Drug Interactions

Part II. Antibiotics
Chapter 4. The Aminoglycoside Antibiotics
Chapter 5. Vancomycin

Part III. Cardiovascular Agents
Chapter 6. Digoxin
Chapter 7. Lidocaine
Chapter 8. Procainamide/N-Acetyl Procainamide
Chapter 9. Quinidine

Part IV. Anticonvulsants
Chapter 10. Phenytoin
Chapter 11. Carbamazepine
Chapter 12. Valproic Acid
Chapter 13. Phenobarbital/Primidone
Chapter 14. Ethosuximide

Part V. Immunosuppressants
Chapter 15. Cyclosporine
Chapter 16. Tacrolimus

Part VI. Other Drugs
Chapter 17. Lithium
Chapter 18. Theophylline

Author

Larry A. Bauer, Pharm.D. is a Professor at the University of Washington School of Pharmacy and has been on the faculty since 1980. He also holds an adjunct appointment at the same rank in the Department of Laboratory Medicine where he is a toxicology consultant. He received his Bachelor of Science in Pharmacy degree (1977) from the University of Washington, and his Doctor of Pharmacy degree (1980) from the University of Kentucky. He also completed an ASHP-accredited hospital pharmacy residency (1980) specializing in clinical pharmacokinetics from A. B. Chandler Medical Center at the University of Kentucky under the preceptorship of Dr. Paul Parker. Dr. Bauer is a fellow of the American College of Clinical Pharmacology and the American College of Clinical Pharmacy. Dr. Bauer's specialty area is in clinical pharmacokinetics, and he teaches courses and offers clinical clerkships in this area. He is the author of Applied Clinical Pharamcokinetics (McGraw-Hill, 2001) His research interests include the pharmacokinetics and pharmacodynamics of drug interactions, the effects of liver disease and age on drug metabolism, and computer modeling of population pharmacokinetics. Dr. Bauer is a member of several clinical pharmacology and clinical pharmacy professional organizations. He is a reviewer for several scientific publications, was Consulting Editor of Clinical Pharmacy (1981 - 1990) and Field Editor of ASHP Signal (1981 - 1983), and is currently on the Editorial Boards of Clinical Pharmacology and Therapeutics and Antimicrobial Agents and Chemotherapy. Dr. Bauer has precepted post-doctoral fellows in clinical pharmacokinetics and pharmacodynamics who currently have faculty appointments in schools of pharmacy or are employed in pharmaceutical industry.