Penile Carcinoma. Therapeutic Principles and Advances

Mechanism of Carcinogenesis and Progression.- Pathologic Features of Invasive Penile Carcinomas and Precursor Lesions.- Characterization of Penile Cancers with Comprehensive Genomic Profiling.- Functional and Psychosocial Impact of Penile Cancer Treatments.- Penile Sparing Surgical and Non-Surgical Approaches.- Management of Primary Penile Tumors - Partial and Total Penectomy.- In the Clinical Setting of Non-Palpable/Non-Bulky Inguinal Nodes.- Management of Bulky Inguinal/Pelvic Metastases in Squamous Penile Cancer.- Neoadjuvant and Adjuvant Multimodality Treatments for Patients with Lymph Node Involvement.- Management of Locally Recurrent Penile Cancer.- Management of Metastatic Penile Cancer.- Overview of Insightful Systemic Approaches.- Clinical Trials Corner.

This book provides a comprehensive and state-of the-art approach to caring for penile carcinoma patients and provides foundational information related to the molecular pathways implicated in penile carcinogenesis and progression. Penile carcinoma remains one of the most debilitating and life-altering malignancies to affect men, with significant impacts on quality of life, erectile function/sexual activity, and length of life. This book illuminates recent advances in penile cancer sparing treatment approaches and oncologically appropriate therapeutic options that help to maintain quality of life, sexual function, and intimacy for patients. It also elucidates recent understandings of human papilloma virus (HPV) and non-HPV driven pathways, which are suspected to have distinct treatment responses and prognoses. The book explores the management of inguinal lymph nodes in the setting of penile cancer, which can now be managed with the integration of key surgical principles/techniques including the adoption of minimally invasive surgery. Considering a multidisciplinary treatment approach for patients exhibiting either locally advanced or more widespread metastatic disease, the book introduces novel systemic therapies currently in development. Further, this book raises clinician awareness of the significant psychosocial impact of penile carcinoma on patients and their families.

Penile Carcinoma: Therapeutic Principles and Advances provides readers with the necessary knowledge and insight to care for penile cancer patients with the use of truly state-of-the-art diagnostic and therapeutic approaches. Cancer patients and their families will greatly benefit from adoption of these principles and the accessibility of such advances to their personalized care.