Endometriosis Pathogenesis, Clinical Impact and Management

Chapter 1. Endocrine disruptors and risk of endometriosis.- Chapter 2. Metabolomic characteristics in endometriosis patients.- Chapter 3. Can we diagnose early endometriosis with ultrasound rather than laparoscopy?.- Chapter 4. Neurotrophins and cytokines in endometriosis pain.- Chapter 5. Endometriosis induced pain: the treatment strategy.- Chapter 6. Management of endometriosis in teenagers.- Chapter 7. The etonogestrel contraceptive implant as a therapy for endometriosis.- Chapter 8. Impact of endometrioma surgery on ovarian reserve.- Chapter 9. What is the place of surgery of deep endometriosis in infertile and pelvic pain patients?.- Chapter 10. Endometriosis and Infertility: surgery and IVF: when, why and outcomes.- Chapter 11. ART and Endometriosis : problems and solutions.- Chapter 12. Morphokinetics in embryos from patients with endometriosis.- Chapter 13. Endometriosis and cancer: prevention and diagnosis.- Chapter 14. Medical management of endometriosis, present and future with special reference to MHT in the patient previously diagnosed with endometriosis.- Chapter 15. Endometriosis and Menopause: Realities and Management.

This volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life.

It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy.

This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.

Prof. Genazzani has been Professor and Director of the Department of Obstetrics and Gynecology of the Universities of Cagliari, Modena and Pisa from 1980 to 2012. He is President of the International Society of Gynecological Endocrinology (ISGE), President of the European Society of Gynecology (ESG), General Secretary of the International Academy of Human Reproduction (IAHR), Fellow ad eundem of the Royal College of Obstetricians and Gynecologists, Fellow at the American College of Obstetricians and Gynecologists. Prof. Genazzani was Editor-in-Chief of Gynecological Endocrinology from 1987 to 2019. Prof. Genazzani since 2020 is Editor-in-Chief of Gynecological and Reproductive Endocrinology and Metabolism GREM, an official Open-Access Journal of the International Society of Gynecological Endocrinology (ISGE). He is author of more than 850 papers in peer reviewed journals and Editor of more than 51 books.

Michelle NISOLLE is Professor of Gynaecology, President of the Obstetrics and Gynecology Department at the University of Liege (ULiege) and Head of University GYN/OBST Department at CHU Liege (site CHR Liege) in Belgium. Her clinical activity is focused on the endoscopic management of benign pathology (especially endometriosis), and she is particularly involved in endoscopic surgery teaching. She is vice -president of the Executive board at ESG, past coordinator of reproductive surgery SIG at ESHRE, executive board member at ESGE, and member of WES and ISGE. From 2017, she is also Belgian associated member at the "Academie royale de Medecine de Belgique". Professor Nisolle is a reviewer for several international journals (Fertility and Sterility as Superior Reviewer, Human Reproduction, International Journal of Obstetrics and Gynaecology, Gynecologic and Obstetric Investigation, Surgical Endoscopy, "Gynecologie, Obstetrique et Fertilite", Acta Neurologica Belgica, and The Lancet). She is an editorial board member in Fertility and Sterility. Since 2018, she is also Editor-in-Chief of "European Gynecology and Obstetrics" EGO, the official journal of ESG. Her research is focused primarily on endometriosis and in particular on its physiopathogenesis. The second theme of her research concerns the ovarian cryopreservation. She is author and co-author of more than 143 book chapters and 269 publications in national and international journals.

Felice Petraglia is the new head of the Maternal and Child Department and professor of Obstetrics and Gynecology at Careggi University Hospital, Florence, Italy. He is the former head of the Obstetrics and Gynecology at the University of Siena, Italy. Since 2004 he has been an adjunct professor at the Department of Obstetrics and Gynecology at University of Toronto, Canada. He is a fellow ad eundem of the Royal College of Obstetricians and Gynecologists (RCOG), member of Steering Committee WHO Sexual and Reproductive Health Guideline Development Group and member of the Pontificial Academy for Life. Prof. Petraglia has served as President of the Society for Gynecologic Investigation. He was also a member of the Board and Committees of FIGO, ISGE, ESHRE and EBCOG and was a consultant to the Ministry of Health and Ministry of University in Italy. He is editor-in-chief of Human Reproductive Update, and section head of Reproductive Endocrinology and Infertility at Faculty 1000 Medicine. He is a member of the Editorial Board of Reproductive Sciences, the Journal of Endometriosis and Pelvic Pain Disorders, and Gynecological Endocrinology

Robert N. Taylor, MD, PhD is Professor of Obstetrics and Gynecology and Assistant Dean for Student and Academic Affairs at the Jacobs School of Medicine and Biomedical Sciences of the University at Buffalo. Previously, he was Professor of Obstetrics and Gynecology at the University of Utah, Wake Forest University, Emory University and past Director of the Center for Reproductive Sciences at the University of California, San Francisco (UCSF). From 1994-95 Taylor was a visiting scientist in the laboratory of Edwin Milgrom, MD, DSc at the Universite de Paris XI and served on the Collegio dei Docenti for the Ph.D. Program in Medical Biotechnology at the University of Siena. He has been a member of the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, and the California Institute for Regenerative Medicine. Taylor received the American Society for Reproductive Medicine Distinguished Researcher Award (2007) and he was Past President of the Society for Reproductive Investigation (2010-11) and honorary secretary of the World Endometriosis Society (2011-17).