Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease

I Introduction to Diffuse Parenchimal Lung Disease.- 1 Diffuse Parenchymal Lung Disease: A Clinical Overview.- 2 Radiologic-pathologic Correlations in Diffuse Parenchymal Lung Disease.- 3 Multidisciplinary discussion in Diffuse Parenchymal Lung Disease.- II Transbronchial cryobiopsy.- 4 Cryobiopsy: Physics.- 5 Cryobiopsy: How it Happened.- 6 Technique and equipment in Transbronchial Cryobiopsy.- 7 Complications in Transbronchial Cryobiopsy.- 8 Immunohystochemistry and Molecular Biology in Transbronchial Cryobiopsy.- III Clinical role of Transbronchial Cryobiopsy.- 9 The Diagnostic Yield of Transbronchial Cryobiopsy.- 10 Clinical Meaning of Transbronchial Cryobiopsy.- 11 Pathologic considerations in Transbronchial Cryobiopsy.- 12 Future perspectives for Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease.- IV Case series.- 13 Idiopahic Pulmonary Fibrosis.- 14 Chronic hypersensitivity pneumonitis.- 15 Other granulomatoses.- 16 Nonspecific interstitial pneumonia.- 17 Collagen vascular diseases.- 18 Smoking related ILDs.- 19 Lymphangioleiomyomatosis.- 20 Pleuroparenchymal fibroelastosis.- 21 Acute lung injury.- 22 Neoplasms.- 23 Rarities

This book presents both theoretical and practical aspects of transbronchial cryobiopsy, a new diagnostic technique for the detection of diffuse parenchymal lung disease that is attracting great interest in the scientific community. In the context of a multidisciplinary discussion, comprising radiologic-pathologic correlations, the authors examine the technical and safety issues - such as equipment, endoscopic setting, anesthesiologic approaches and bleeding control - on one hand, and the diagnostic yield and clinical meaning on the other.

The volume offers several case studies - including idiopathic pulmonary fibrosis, granulomatous disorders, interstitial pneumonias, rare lung disseminated tumors- that illustrate the high diagnostic yield and safety of this innovative technique. The book appeals to a wide readership, including residents, pulmonologists with expertise in diffuse parenchymal lung diseases, interventional pulmonologists, thoracic radiologists, pathologists, anesthesiologists, internists and rheumatologists.

Venerino Poletti is specialized in both respiratory medicine and anatomic pathology. He started his career as a surgical pathologist before becoming a clinician after 8 years. However, he didn't abandon his first interest, and continued to run the bronchioalveolar lavage (BAL) and cytology laboratory at the Dept of Pulmonology of the Maggiore Hospital in Bologna, Italy.

His investigations cover a wide field: complications in patients with HIV infection; the role of BAL in the detection of malignancies; new radiologic features in diffuse parenchymal lung diseases; the definition of clinico-radiologic and pathologic aspects of bronchiolitis; the role of TBNA in the diagnosis of sarcoidosis; the identification of pathogenetic events in idiopathic pulmonary fibrosis; and lastly new, less invasive methods of performing lung biopsies in patients with diffuse lung diseases. He introduced endoesophageal ultrasound (EUS) investigations by pulmonologists in Italy, and is an internationally recognized expert in transbronchial cryobiopsy. He is Head of the Department of Diseases of the Thorax at the GB Morgagni Hospital, Forli (I) and Full Professor of Respiratory Medicine at the Aarhus University (DK).