FIELDS Virology, Vol. 4: Fundamentals

Contributors
Preface
Introduction
1 Virology: From Contagium
Fluidum to Virome 1
L. W. Enquist • Vincent R. Racaniello
2 Principles of Virology 21
Julie K. Pfeiffer • Richard C. Condit •
John W. Schoggins
3 Principles of Virus Structure 50
Stephen C. Harrison
4 Virus Entry and Uncoating 96
Jason Mercer
5 Viral Replication Strategies 117
Sean P . J. Whelan
6 Virus Assembly and Maturation 140
Christopher J. Neufeldt • Eric Hunter
7 Metabolism and Viral Infection 170
James C. Alwine • John G. Purdy
8 Pathogenesis of Viral Infection 191
Thomas E. Morrison • Mark T. Heise
9 Innate Immunity to Viruses 227
Akiko Iwasaki • John W. Schoggins • Sun Hur
10 The Adaptive Immune
Response to Viruses 247
Dennis R. Burton • Shiv Pillai • Young S. Hahn •
Thomas J. Braciale
11 Tumor Virology 286
12 Evolution of Viral Proteins 312
Eugene V. Koonin • Mart Krupovic
13 Epidemiology 333
Amy K. Winter • William J. Moss
14 Antiviral Agents 353
Donald M. Coen • Mark N. Namchuk • Daniel R. Kuritzkes
15 Immunization Against
Viral Diseases 398
James E. Crowe Jr
16 Diagnostic Virology 448
Alexander L. Greninger • David Wang •
Gregory A. Storch • Keith R. Jerome
17 Giant Viruses 467
Jônatas Santos Abrahão
18 Plant Viruses 494
Anne E. Simon • Kristiina Mäkinen • Yi Li •
Jeanmarie Verchot
19 Insect Viruses 527
Paul D. Friesen
20 Viruses and Prions of Yeasts,
Fungi, and Protists 560
Reed B. Wickner
21 Bacteriophages 590
Graham F. Hatfull
22 Prions 624
Byron Caughey • Valerie L. Sim
Index 655

Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Fundamentals, Seventh Edition, edited by Drs. Peter Howley and David M. Knipe, along with volume associate editors Drs. Lynn Enquist, Jeffrey I. Cohen, Eric O. Freed, Blossom A. Damania, and Sean P. J. Whelan, focuses on the basic principles of virology and reflects recent advances in this dynamic field.  

Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as undergraduate and graduate students interested in virology.  

• Includes chapters on virus structures, essential viral functions, immune responses to viral infections, viral epidemiology, viral diagnostics, and viral therapies 

• Up to date discussions of antiviral therapies and vaccine strategies 

• Features more than 300 full-color illustrations, including key figures for use as lecture slides 

• Provides quick, flexible access to current information both in print and in an improved eBook format 

• Discusses virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, viral persistence and latency for HIV, and mechanisms of viral oncogenesis for HPV, KSHV and the hepatotropic viruses  

Newly revised Field’s Virology volumes, available in print and eBook format: 

• Emerging Viruses 
• DNA Viruses 
• RNA Viruses 
• Fundamental Virology  

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