Introduction To Clinical Infectious Diseases. A Problem-Based Approach

Infections of the skin and lymph nodes.- Bacterial Infections of the Skin and Skin Structures.- Febrile Exanthems of Childhood - A Child with Fever and Rash.- Acute and Chronic Lymphadenitis Swollen glands.- Infections of the eye.- Infectious conjunctivitis Pink Eye, Red Eye, and More Complex Conditions.- Keratitis: A red painful eye.- Endophthalmitis.- Infections of the respiratory tract.- Otitis, Sinusitis, and Mastoiditis Ear or Facial Pain Following a Common Cold.- Pharyngitis and Pharyngeal Space Infections fever, sore throat, difficulty swallowing.- Pertussis and Pertussis Syndrome a whooping cough.- Laryngitis, Tracheitis, Epiglottitis, and Bronchiolitis, Sore Throat, Change in Voice, Fever or a Wheezing Infant in Respiratory Distress.- Community Acquired Pneumonia.- Atypical Pneumonia.- Pneumonia Caused by Endemic Fungi, Dry Cough and Fever After Visiting or Living in an Endemic Area.- Tuberculosis.- Influenza.- SARS CoV 2: Acute Infections, Multisystem Inflammatory Syndrome in Children, and Long-Term Sequelae.- Infections of the heart.- Infective Endocarditis.- Infectious Myocarditis I can’t breath and my heart is racing.- Acute Rheumatic Fever licks the joints, but bites the heart.- Kawasaki Disease.- Infections of the liver and intestinal tract.- Infectious Hepatitis Fever, abdominal pain, and elevated serum aminotransferases.- Liver Abscess fever with right sided abdominal pain.- Infectious Gastroenteritis diarrhea with fever and vomiting.- Infections of the urogenital tract.- Urinary Tract Infections fever, dysuria and flank pain.- Human Papillomavirus Infection Clinically Silent Progression to Cancer and Genital Warts.- Prostatitis, Epididymitis, and Orchitis Acute Scrotal Pain.- Vaginitis, Mucopurulent Cervicitis, and Pelvic Inflammatory Disease Vaginal Discharge.- Congenital and Perinatal Infections Newborn with microcephaly, blueberry muffin rash, and hepatosplenomegaly.- Infections of the central nervous system.- Myelitis and Acute Flaccid Paralysis rapid onset of severe muscle weakness.- Aseptic Meningitis Fever, Headache and A Stiff Neck Not Looking So Sick.- Bacterial Meningitis Fever, Headache and A Stiff Neck Looking Pretty Sick.- Eosinophilic Meningitis.- Parameningeal Infections Fever, Headache, and An Abnormal Neurologic Examination.- Meningoencephalitis fever, altered level of consciousness, seizures.- Polyomavirus Infections.- Toxin-mediated diseases, bloodstream infections and their complications.- Tetanus, Diphtheria, and Botulism.- Toxic Shock Syndrome Fever, Erythroderma, Conjunctivitis, Shock.- Bacterial Toxin Mediated Food Poisoning and Spore Associated Foodborne Toxicoinfection.- Clostridioides difficile colitis.- Bacteremia and Bacterial Sepsis The Patient with A Positive Blood Culture.- Catheter Related Bloodstream Infections.- Osteomyelitis and Septic Arthritis fever and limp.- Candidiasis The Laboratory Report States that there are Yeast in the Blood Culture.- Tick and mosquito borne diseases and tropical infections of global importance.- Lyme Disease.- Rocky Mountain Spotted Fever and Other Rickettsioses Fever, Headache, and Rash After Traveling to, or Living in an Endemic Area.- Malaria Fever and Pallor While Living in, Traveling to, or Returning From Just About Anywhere in the Tropics or Subtropics.- Yellow Fever and Dengue Fever, Hepatitis, and Jaundice in a Returning Traveler Fever, Retro-Orbital Headache, Generalized Myalgias, Arthralgias and Bone Pain in a Returning Traveler.- Mpox A fever illness with a vesicular rash.- Chagas Disease South American Trypanosomiasis Fever, Myalgias, and Acute Myocarditis in a Traveler Returning From a Trip to the Amazon Rain Forest.- African trypanosomiasis African sleeping sickness.- Leptospirosis A Farmer with Fever, Conjunctival Suffusion, and Rash Who Subsequently Develops Jaundice and Hepatomegaly.- Leprosy A Chronic Skin Lesion that Feels Numb.- Human Infections Caused by Tapeworms.- Neurocysticercosis First Time Seizure in a Recent Immigrant From Mexico.- Human Infections Caused by Trematodes.- Human Infections Caused by Nematodes: Roundworms.- Human immune deficiency virus.- Human Immunodeficiency Virus I History, Epidemiology, Transmission, and Pathogenesis.- Human Immunodeficiency Virus II Clinical Presentation, Opportunistic Infections, Treatment, and Prevention Fever, Pharyngitis, and Lymphadenopathy with Prolonged FatigueWeight Loss with Recurrent Infections.- Post-Exposure and Pre-Exposure HIV Prophylaxis.- Principles of Antibiotic Stewardship.- Principles of Antimicrobial Stewardship.- Essentials of diagnostic microbiology.- Essentials of Diagnostic Microbiology.

The field of infectious diseases drifts and shifts as new pathogens emerge or re-emerge, new treatment modalities become available, and new prevention strategies are implemented. Students of medicine and the clinically experienced teachers who help to steer their education will benefit from Clinical Infectious Diseases: A Problem-Based Approach because each chapter first defines a clinical diagnosis and moves to descriptions of common and/or classic causes of the problem while including tables, lists and descriptions of the rare and unusual etiologies we all find so fascinating. General management approaches are included to help build foundations of clinical care of infections including, but not limited to the administration of antibiotics. Reminders of classic complications seen with specific infections and/or their treatment are used to emphasize the importance of ongoing vigilance even after a specific microbiologic diagnosis has been identified. Common causes of each problem are emphasized. Unusual and rare causes are mentioned briefly with clinical clues about when to consider them. Case descriptions are used to support, facilitate, and refine the learner’s deductive clinical reasoning skills.

The book is written for a broad audience of medical trainees by a diverse group of medical experts, then edited by an infectious disease physician-scientist-educator to maintain a primary focus on the infection aspects of each problem. Basic content is reviewed first, then layered with advancing complexity. Call-out boxes are used to emphasize key concepts while figures and tables provide insights into more complex, rare but important and/or classic features of infection. As such, the book will appeal to a broad range of students and trainees from those just entering the health care field to those who have already reached subspecialty training.

Dr. Joseph Domachowske 

Department of Pediatrics and Microbiology & Immunology

SUNY Upstate Medical University, Syracuse, New York, USA