The WASHINGTON Manual Hematology and Oncology Subspecialty Consult

Contents
Contributors v
Department Chair’s Note viii
Preface ix
PART I. HEMATOLOGY
Introduction and Approach to Hematology 3
Christine Auberle
White Blood Cell Disorders: Leukopenia and Leukocytosis 11
Nicole C. Foley
Red Blood Cell Disorders 25
Sana Saif Ur Rehman
Platelets: Thrombocytopenia and Thrombocytosis 39
Joshua I. Siner
Introduction to Coagulation and Laboratory Evaluation of
Coagulation 53
Nicholas C. Spies and Ronald Jackups Jr
Thrombotic Disease 64
Joshua I. Siner and Kristen M. Sanfilippo
Coagulopathy 79
Joshua I. Siner
Bone Marrow Failure 92
Constantine N. Logothetis and Stefan P. Tarnawsky
Myelodysplastic Neoplasms and Clonal Hematopoiesis 102
Constantine N. Logothetis and Stefan P. Tarnawsky
Myeloproliferative Neoplasms 115
Imran Nizamuddin and Amy W. Zhou11. Transfusion Medicine 138
Nathan B. McLamb and Suzanne R. Thibodeaux
12. Sickle Cell Disease 151
Oladipo Cole
13. Drugs That Affect Hemostasis: Anticoagulants,
Thrombolytics, and Antifibrinolytics 165
Sasha Haarberg
14. Plasma Cell Disorders 181
Michael J. Slade
PART II. ONCOLOGY
15. Introduction and Approach to Oncology 193
Mia C. Weiss
16. Cancer Biology 206
Jared Cohen
17. Introduction to Cancer Genomics 213
Giordano F. Cittolin Santos and Daniel Morgensztern
18. Cancer Therapeutics 217
Sasha Haarberg
19. Introduction to Radiation Oncology 249
Mustafaa Mahmood, Anthony Apicelli, Imran Zoberi,
and Joanna C. Yang
20. Introduction to Immunotherapy 258
Brett H. Herzog, Tanner M. Johanns, and Jeffrey P. Ward
21. Breast Cancer 267
Katherine Clifton
22. Lung Cancer 288
Christine Auberle and Saiama N. Waqar
23. Colorectal Cancer 299
Patrick M. Grierson
24. Other Gastrointestinal Malignancies 307 Malignant Melanoma 325
Favour Ayomide Akinjiyan, Renee Morecroft, Alice Zhou,
and George Ansstas
Head and Neck Cancer 333
Peter Oppelt
Sarcoma 340
Mia C. Weiss
Endocrine Malignancies 350
Michael D. Iglesia, Peter Oppelt, and Nikolaos A. Trikalinos
Urologic Malignancies 369
Melissa A. Reimers
Gynecologic Oncology 381
Andrea R. Hagemann
Primary Brain Tumors 400
Kaiden Barozinsky, Kaleigh Roberts, and Omar Hameed Butt
Leukemias 406
Michael J. Slade
Lymphoma 427
Ryan Day
Introduction to Hematopoietic Stem Cell Transplantation 441
Giulia Petrone and Amanda F. Cashen
Human Immunodeficiency Virus–Associated Malignancies 456
Thomas A. Odeny
Cancer of Unknown Primary (CUP) 468
Michael D. Bern and Olivia Aranha
Supportive Care in Oncology 475
Oladipo Cole and Angela C. Hirbe
Oncologic Emergencies 490
Brendan Knapp
Index 501

Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 5th Edition, provides quick access to the essential information needed to evaluate a patient on a hematology-oncology subspecialty consult service. Edited by Drs. Brian A. Van Tine and Meagan A. Jacoby, this best-selling manual offers state-of-the-art content, including coverage of new therapies such as CAR T-cell therapy, new anti-cancer drugs, and new biomarkers and therapeutic targets. Ideal for fellows, residents, and medical students rotating on hematology and oncology subspecialty services, the manual is also useful as a first-line resource for advanced practice providers, general internal medicine physicians, Hem/ONC fellows, and other primary care providers.

• Thoroughly revised to include new therapies such as PD-1 inhibitors for Hodgkin lymphoma, CAR T-cell therapy in NHL and multiple myeloma, gene therapy for sickle cell disease, CAR T-cell therapies and management of CRS and neurotoxicity, and more
• It presents clinically oriented information like symptoms, signs, and problems in a quick-reference, bulleted list format for easy, everyday reference
• Shares the knowledge and experience of a new co-editor of the Hematology section, Dr. Meagan Jacoby
• Provides updated references for additional information on key topics
• Written by fellows and  faculty from the Washington University School of Medicine in St. Louis

The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by WoltersKluwer Health under license from Washington University.

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