NELSON's Pediatric Antimicrobial Therapy 2024

Introduction
Notable Changes to 2024 Nelson’s Pediatric Antimicrobial Therapy, 30th Edition
1. Antimicrobial Therapy According to Clinical Syndromes
A. Skin and Soft Tissue Infections
B. Skeletal Infections
C. Eye Infections
D. Ear and Sinus Infections
E. Oropharyngeal Infections
F. Lower Respiratory Tract Infections
G. Cardiovascular Infections
H. Gastrointestinal Infections
I. Genital and Sexually Transmitted Infections
J. Central Nervous System Infections
K. Urinary Tract Infections
L. Miscellaneous Systemic Infections
2. Antimicrobial Therapy for Neonates
A. Recommended Therapy for Select Neonatal Conditions
B. Antimicrobial Dosages for Neonates
C. Aminoglycosides
D. Vancomycin
E. Use of Antimicrobials During Pregnancy or Breastfeeding
3. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens
A. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Positive)
B. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Negative)
C. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Anaerobes)
D. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens
4. Choosing Among Antibiotics Within a Class: Beta-lactams and Beta-lactamase Inhibitors, Macrolides, Aminoglycosides, and Fluoroquinolones
5. Preferred Therapy for Specific Fungal Pathogens
A. Overview of More Common Fungal Pathogens and Their Usual Pattern of Antifungal Susceptibilities
B. Systemic Infections
C. Localized Mucocutaneous Infections
6. Choosing Among Antifungal Agents: Polyenes, Azoles, and Echinocandins
7. Preferred Therapy for Specific Viral Pathogens
A. Overview of Non-HIV, Non–hepatitis B or C Viral Pathogens and Usual Pattern of Susceptibility to Antivirals
B. Overview of Hepatitis B or C Viral Pathogens and Usual Pattern of Susceptibility to Antivirals
C. Preferred Therapy for Specific Viral Pathogens
8. Choosing Among Antiviral Agents
9. Preferred Therapy for Specific Parasitic Pathogens
A. Select Common Pathogenic Parasites and Suggested Agents for Treatment
B. Preferred Therapy for Specific Parasitic Pathogens
10. Choosing Among Antiparasitic Agents: Antimalarial Drugs, Nitroimidazoles, Benzimidazoles, and Neglected Tropical Diseases
11. How Antibiotic Dosages Are Determined by Use of Susceptibility Data, Pharmacodynamics, and Treatment Outcomes
12. Approach to Antibiotic Therapy for Drug-Resistant Gram-negative Bacilli and Methicillin-Resistant Staphylococcus aureus
13. Antibiotic Therapy for Children With Obesity
14. Sequential Parenteral-Oral Antibiotic Therapy (Oral Step-down Therapy) for Serious Infections
15. Antimicrobial Prophylaxis/Prevention of Symptomatic Infection
A. Postexposure Antimicrobial Prophylaxis to Prevent Infection
B. Long-term Antimicrobial Prophylaxis to Prevent Symptomatic New Infection
C. Prophylaxis of Symptomatic Disease in Children Who Have Asymptomatic Infection/Latent Infection
D. Surgical/Procedure Prophylaxis
16. Approach to Antibiotic Allergies
17. Antibiotic Stewardship
18. Systemic and Topical Antimicrobial Dosing and Dose Forms
A. Systemic Antimicrobials With Dosage Forms and Usual Dosages
B. Topical Antimicrobials (Skin, Eye, Ear, Mucosa)
Appendix: Nomogram for Determining Body Surface Area
References
Index

Completely updated and revised, the 30th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children.

For each disease, the authors provide a commentary to help select the best of all antimicrobial choices.
Drug descriptions cover all antimicrobial agents available today and include complete information about dosing regimens. Free updates are available at aap.org/Nelsons.

New in the 30th Edition

• Updated multiple drug-resistant gram-negative pathogens treatment recommendations with newly approved antibiotics
• Newer antibiotics, beyond vancomycin, to treat MRSA infections
• Updates on children’s influenza, COVID-19, and enterovirus treatments
• Updates on travelers’ diarrhea
• Latest guidelines for treatment of invasive pediatric fungal infections
• New guidelines for treatment of pediatric bacterial arthritis
• Recommendations on hepatitis C virus and cytomegalovirus treatment options

CHAPTERS INCLUDE

• Antimicrobial Therapy According to Clinical Syndromes
• Antimicrobial Therapy for Neonates
• Choosing Among
  • Antibiotics
  • Antifungal Agents
  • Antiviral Agents
  • Antiparasitic Agents
• Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens; Fungal Pathogens; Viral Pathogens; and Parasitic Pathogens
• Approach to Antibiotic Therapy for Drug-Resistant Gram-Negative Bacilli and Methicillin-Resistant Staphylococcus aureus
• Systemic and Topical Antimicrobial Dosing and Dose Forms
• Sequential Parenteral-Oral Antibiotic Therapy (Oral Step-Down Therapy) for Serious Infections
• Antimicrobial Prophylaxis/Prevention of Symptomatic Infection
• Approach to Antibiotic Allergies
• Antibiotic Stewardship
• Antibiotic Therapy for Children With Obesity
• And more…

John S. Bradley, MD, FAAP, has been the Medical Director of the Division of Infectious Diseases at Rady Children's Hospital-San Diego since 1988, and is currently Distinguished Professor of Pediatrics, Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego School of Medicine. He has served on the American Academy of Pediatrics Committee on Infectious Diseases (Red Book Committee) 2004-2010, and the Council of the Pediatric Infectious Diseases Society (PIDS) Council, 2007-2011 where he promoted the development of a PIDS Antimicrobial Stewardship program.

John D. Nelson, MD is Professor Emeritus of Pediatrics at the University of Texas Southwestern Medical Center and Children's Medical Center, the same institution since he started his career back in 1957. At UT Southwestern he established the first formal Pediatric Infectious Disease fellowship program with Dr. Kenneth Haltalin and later Dr. George McCracken. He also went on to establish the National Pediatric Infectious Disease Seminar with Dr. McCracken and in 1982 they founded the Pediatric Infectious Disease Journal for which they continue as Chief Editors. In 1975 Dr. Nelson produced the first edition of the Pocket Book of Pediatric Antimicrobial Therapy which has gone through 20 biennial editions and is now edited by Dr. John Bradley.