Brain and Spinal Tumors of Childhood

List of Contributors

1. Introduction

David A. Walker, Giorgio Perilongo, Roger E. Taylor, and Ian F. Pollack

2. Epidemiology of Childhood Brain Tumors

Richard J. McNally and Paul Graham Fisher

3. Clinical Presentation and Associated Syndromes of Brain Tumor

David Walker, JoFen Liu, and Dhurgsharna Shanmugavadivel

4. Pediatric Central Nervous System Tumors as Phenotypic Manifestation of Cancer Predisposition Syndromes

Giorgio Perilongo, Irene Toldo, and Stefano Sartori

5. Anatomical and Biological Imaging of Pediatric Brain Tumor

Rob A. Dineen, Shivaram Avula, Andrew C. Peet, Giovanni Morana, and Monika Warmuth- Metz

6. Neurosurgical Techniques and Strategies

Jonathan E. Martin, Ian F. Pollack, and Robert F. Keating

7. Radiotherapy for Pediatric Central Nervous System Tumors – Techniques and Strategies

Nicola Thorp

8. Physical and Cognitive Rehabilitation for Children with Brain and Spinal Tumors

Alexandra M. Gaynor, Helen Hartley, and Stephen A. Sands

9. Drug Delivery

Gudrun Fleischhack, Martin Garnett, and Kévin Beccaria

10. Low- grade Glioma Presenting in the Optic Pathways and Hypothalamus (NF1. and Sporadic)

Peter M.K. de Blank, Ian Simmons, Astrid Sehested, and Michael J. Fisher

11. Low- grade Glioma: Principles of Diagnosis and Drug Treatment

Pablo Hernáiz Driever, Olaf Witt, Astrid Gnekow, Daniela Kandels, and Mark Kieran

12. High- grade Glioma

Donald C. Macarthur, Christof M. Kramm, and Matthias A. Karajannis

13. Diff use Intrinsic Pontine Glioma

Katherine E. Warren, Carolyn R. Freeman, and Dannis G. van Vuurden

14. Embryonal Tumors

Simon Bailey and Jeff Michalski

15. Ependymoma in Childhood and Adolescence

Richard Grundy and Eric Bouff et

16. Germ Cell Tumors of the Central Nervous System

Matthew J. Murray, Ute Bartels, and James C. Nicholson

17. Atypical Teratoid / Rhabdoid Tumors – AT/ RT

Michael C. Frühwald, Jaclyn A. Biegel, and Susan N. Chi

18. Craniopharyngioma

Hermann L. Müller, Claire Alapetite, and Jeff rey Wisoff

19. Choroid Plexus Tumors and Meningiomas

Kenneth K. Wong, Elwira Szychot, Jennifer A. Cotter, and Mark Krieger

20. Pediatric Spinal Tumors

Rajiv R. Iyer, Nir Shimony, Mohammad Hassan A. Noureldine, Eric Bouff et, and George I. Jallo

21. Late Eff ects of Treatment for Childhood Brain and Spinal Tumors

Ralph Salloum, Katherine Baum, Melissa Gerstle, Helen Spoudeas, and Susan R. Rose

22. The Power of Patient Advocacy in Pediatric Neuro- oncology

Kathy Oliver, Susan Awrey, Mark Brougham, Gloria Garcia Castellvi, Anita Granero, Rakesh Jalali, Sacha Langton- Gilks, Barrie Littlefi eld, Yuko Moue, Kathy Riley, Bonita Suckling, Hisato Tagawa, and Raees Tonse

Index

This second edition comes at a time of a paradigm shift in understanding of the molecular pathology and neuroscience of brain and spinal tumors of childhood and their mechanisms of growth within the developing brain. Excellent collaborative translational networks of researchers are starting to drive change in clinical practise through the need to test many ideas in trials and scientific initiatives. This text reflects the growing concern to understand the impact of the tumour and its treatment upon the full functioning of the child’s developing brain and to integrate the judgments of the risks of acquiring brain damage with the risk of death and the consequences for the quality of life for those who survive. Information on the principles of treatment has been thoroughly updated. A chapter also records the extraordinary work done by advocates. All medical and allied professionals involved in any aspect of the clinical care of these patients will find this book an invaluable resource.

David A. Walker is Professor Paediatric Oncology, School of Medicine, University of Nottingham, Nottingham, UK

Giorgio Perilongo is Director, Department of Woman’s and Child’s Health, Division of Pediatrics, University of Padua, Padua, Italy

Roger E. Taylor is Professor of Clinical Oncology, College of Medicine, Swansea University; Honorary Consultant Clinical Oncologist, South West Wales Cancer Centre, Singleton Hospital, Swansea, UK

Ian F. Pollack is Chief, Pediatric Neurosurgery, Children's Hospital of Pittsburgh, Leland Albright Distinguished Professor of Neurological Surgery, Vice Chairman for Academic Affairs, Department of Neurological Surgery, Co-Director, UPCI Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA