Inhalation Toxicology

Description

The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the bodythrough the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, ThirdEdition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, thebook comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances.

Topics include:

• Regulatoryaspects of exposure and testing
• Testingequipment and procedures
• Respiratoryallergy and irritation of therespiratorytract
• Riskassessment
• Toxicologytheory
• Toxicologymodeling
• Toxiceffects of some individual toxicants

New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book’s educational utility.

Features

• Emphasizes the relationship between the respiratory system and toxicology of inhaled substances
• Focuses on regulatory aspects of exposure and testing, equipment, procedures, allergies, risk assessment, theory, and modeling
• Includes new chapters on lungs-on-a-chip technology, asbestos fibers, and nanoparticles
• Presents questions and answers at the end of each chapter to enhance educational utility 

Contents

Inhalation Methods and Measurements
Inhalation Risk Assessment at the Environmental Protection Agency
The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances
Emergency Response Planning Guidelines (ERPGs)
Directed Flow Aerosol Inhalation Exposure Systems: Application to Pathogens and Highly Toxic Agents
Whole-Body, Low-Level Sarin Vapor Exposure in Rats: Estimating the Probability of Miosis as a Function of Exposure Concentration and Duration
Application of Intratracheal Instillation Exposure to the Etiological Determination of a Pulmonary Disease Outbreak: Nylon Flock as an Example
The Use of Large Animals in Inhalation Toxicology
Toxic Load Modeling
Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program
Combustion Toxicology
Inhalation Toxicology Mechanisms
Toxicogenomics of Low-Level Nerve Agent Vapor Exposure
Respiratory Sensitization
Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure
Role of Cytokines in Pulmonary Inflammation and Fibrosis Induced by Inhaled Mineral Particles
Hormesis: Implications for Risk Assessment
Nasal Toxicology
Effects of Inhaled Toxicants on the Nose and Nasal Function
Toxicokinetics: Deposition, Absorption, Distribution, and Excretion
Inhalation Toxicology of an Irritant Gas: Historical Perspectives, Current Research, and Case Studies of Phosgene Exposure
Inhalation Toxicology of Riot Control Agents
Chemical Warfare Agents and Nuclear Weapons
Inhalation Toxicology of Metals (Chromium)
Safety Assessment of Therapeutic Agents Administered by the Inhalation Route
Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract
Inhalation Toxicology of Materials
Inhalation Toxicology of Alcohol/Gasoline Fuels: Current Status
Asbestos
The Inhalation Toxicity of Benzene
Carbon Monoxide
Experimental, Clinical, Occupational Toxicology and Forensic Aspects of Hydrogen Cyanide and Particular Reference to Vapor Exposure
The Pharmacology and Toxicology of Inhaled Dusts, Endotoxins, and Glucans
Fluorocarbon Alternatives: Methodologies for Special Studies and Results
Animal Models for Three Major Cigarette-Smoke-Induced Diseases
The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health
Inhalation Toxicology of Biologicals
Health Aspects of Bioaerosols
Emerging Biothreats: Natural and Deliberate
Toxicology Associated with Respiratory Exposures to Fungi (Molds)
Inhalation of Botulinum Toxins
Inhalation of Ricin: Aerosol Procedures, Animal Toxicology, and Therapy
Inhalation Toxicology & Pharmacology of Biologicals and Toxins: Prophylaxis and Therapy

Editor(s) Bio

Harry Salem is the Chief Scientist at the U.S. Army Edgewood Chemical Biological Center. He has been a visiting professor at Drexel University, Rutgers University, Temple University, and the University of Pennsylvania and he has held a variety of positions in the pharmaceutical industry and in commercial toxicology laboratories. He was the editor-in-chief of the Journal of Applied Toxicology and is on the editorial board of the Journal of Inhalation Toxicology. He was the 2001 Society of Toxicology Congressional Science Fellow, and is a Fellow of the New York Academy of Sciences, the American College of ClinicalPharmacology, the American College of Toxicology, and the Academy of Toxicological Sciences.

Sidney A. Katz is a professor of chemistry at Rutgers University. He has been a visiting professor in Canada, England, Germany, Hungary, Slovenia, and South Africa and has held research positions with E.I. duPont de Nemours and Company and with the R.M. Hollingshead Corporation. He has been a research fellow at the U.S. Army Edgewood Chemical Biological Center. His research activity is in environmentalbioanalytical chemistry. From 1997 to 2002, he was a New Jersey commissioner for hazardous waste facilities siting.

Reviews

"The editors' thoughtful treatment is absolutely stunning as is their capacity to guide authors toward creative, comprehensive entries while also maintaining a degree of uniformity among topics … InhalationToxicology has been a standard reference and textbook for respiratory scientists."
—J. Thomas Pierce, PhD, Navy Environmental Health Center, in Doody’s Review Service