Handbook of Radiopharmaceuticals. Methodology and Applications

Foreword
Preface
List of Contributors
About the Editors
Abbreviations

PART I: INTRODUCTION TO RADIOPHARMACEUTICALS

• 1. Targeted Diagnostic Radiopharmaceuticals: Design Options for Small Molecule Radiotracers
  Michael R. Kilbourn
• 2. Concepts and Issues for Therapeutic Radiopharmaceuticals
  Alexandra R. Sowa Dumond and Peter J. H. Scott

PART II: PRODUCTION OF RADIONUCLIDES

• 3. Production of Short Half-life PET Radionuclides
  Michael R. Kilbourn, Melissa E. Rodnick and Mara Clark
• 4. Production of Radionuclides used in SPECT
  Salma Jivan and Thomas J. Ruth
• 5. Production of Therapeutic Radionuclides
  C. Shaun Loveless and Suzanne E. Lapi

PART III: SYNTHETIC METHODS FOR RADIOPHARMACEUTICALS

• 6. Synthesis of 13N- and 15O-labeled Radiopharmaceuticals
  Krishna R. Pulagam, Vanessa Gómez-Vallejo, Fernando López-Gallego, Luka Rejc and Jordi Llop
• 7. Radiochemistry with Carbon-11
  Stephen Thompson, Steven Kealey, Selena M. Sephton and Franklin I. Aigbirhio
• 8. Fluorine-18 Radiochemistry
  Allen F. Brooks, Katarina J. Makaravage, Jay Wright, Melanie S. Sanford and Peter J. H. Scott
• 9. Synthesis of 68Ga-labeled Radiopharmaceuticals
  Benjamin P. Burke and Stephen J. Archibald 
• 10. Cu-Mediated Radiohalogenation of Organoboranes
  Sean W. Reilly and Robert H. Mach
• 11. The radiochemistry of zirconium
  Jason P. Holland
• 12. 99mTc Radiopharmaceutical Chemistry
  Dionysia Papagiannopoulou

PART IV: PRACTICAL ASPECTS OF RADIOPHARMACEUTICAL PRODUCTION AND USE

• 13. Automated Synthesis Modules for PET Radiochemistry
  Laura Bruton and Peter J. H. Scott
• 14. Automation of PET Radiopharmaceutical Quality Control
  Arkadij Elizarov
• 15. Moving PET Drugs from the Lab to the Patient in USA
  David W. Dick
• 16. Moving from the Lab to the Patient in Asia
  Dae Yoon Chi
• 17. Moving a radiotracer form bench to bedside in Europe
  Koen Vermeulen, Alfons Verbruggen, Guy Bormans and Frederik Cleeren

PART V: MAJOR APPLICATIONS OF RADIOPHARMACEUTICALS

• 18. Radiopharmaceuticals in Oncology
  Jeroen A.C.M. Goos, Outi Keinänen, Brian M. Zeglis and Jason S. Lewis
• 19. Neurological applications of Radiopharmaceuticals
  Mehdi Djekidel and Nicolaas I. Bohnen
• 20. Cardiac Applications of Radiopharmaceuticals
  John P. Bois and Robert J. Gropler
• 21. Radiopharmaceuticals in Pediatric Nuclear Medicine
  Scott E. Snyder, Elizabeth R. Butch and Barry L. Shulkin
• 22. PET Imaging in Drug Discovery and Development
  David J. Donnelly

INDEX

The second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more.