Control Of Breathing During Sleep. From Bench To Bedside

Foreword

Preface

About the Editors

List of Contributors

SECTION I. ANATOMY, DEVELOPMENT, AGING, AND MECHANISMS OF CONTROL OF VENTILATION

1. Anatomy of the Respiratory Neural Network

Christopher A. Del Negro and Christopher G. Wilson

2. Chemoreception: Pathways, Plasticity, and Pathophysiology

Barbara J. Morgan and Jerome A. Dempsey

3. Developmental Changes in the Respiratory System of the Neonate-Child

Ahuva Brown, Liran Tamir Hostovsky, and Estelle B. Gauda

4. Control of Breathing in Older Adults

Susmita Chowdhuri

5. Breathing Control in Exercise

Philippe Haouzi

6. Control of the Upper Airway during Sleep

Leszek Kubin

SECTION II. PATHOPHYSIOLOGY OF SLEEP-DISORDERED BREATHING

7. Pathophysiology of Sleep-Disordered Breathing in Children and Neonates

Sofia Konstantinopoulou and Ignacio E. Tapia

8. Pathogenesis of Sleep-Disordered Breathing in Adults: Overview

Thomas M Tolbert, Indu Ayappa, and David M Rapoport

9. Risk and Causality by Genetics, Gender, and Age

Moshe Prero, Nardine Zakhary, Sally Ibrahim, and Kingman P. Strohl

10. The Influence of Cerebral Blood Flow and Cerebrovascular Responsiveness on Ventilatory Control

Jay M. J. R. Carr, Gustavo Vizcardo-Galindo, and Philip N. Ainslie

11. Central Apnea: Propensity and Plasticity

M.S. Badr

SECTION III. SLEEP-DISORDERED BREATHING IN DIFFERENT CONDITIONS AND DISEASE STATES

12. Sleep-Disordered Breathing due to Heart Failure

S. Javaheri and R. Germany

13. Breathing at Altitude

David Patz

14. Sleep-Disordered Breathing Associated with Chronic Lung Diseases

Bernie Y Sunwoo, Ana Sanchez-Azofra, and Atul Malhotra

15. Obesity Hypoventilation Syndrome

Amanda Piper

SECTION IV. PATHOPHYSIOLOGY-DIRECTED THERAPIES FOR SLEEP-DISORDERED BREATHING

16. Effect of Positive Airway Pressure on Ventilatory Control and Sleep-Disordered Breathing

James A Rowley

17. Mild Intermittent Hypoxia and Supplemental Oxygen: Potential Therapeutic Interventions to Treat Breathing Instability

Sreenavya Gandikota and Jason H. Mateika

18. Pharmacological Management of Sleep-Disordered Breathing

Thomas J. Altree, Peter G. Catcheside, Sutapa Mukherjee, and Danny J. Eckert

19. Neural Mechanisms Regulating Opioid-Induced Respiratory Depression and Therapeutic Strategies to Alleviate the Respiratory Side-Effects of Opioid Drugs

Jean-Philippe Rousseau and Gaspard Montandon

20. Pharmacologic Intervention Studies to Mitigate Breathing Instability – Animal Studies

Carla Freire, Lenise J. Kim, and Vsevolod Y. Polotsky

Index

 

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This book describes control of ventilation during sleep in both health and disease states. The topics are presented in a fashion that can be easily comprehended with many figures to illustrate complex concepts. Thus, a wide range of topics, starting from the site of normal respiratory rhythm generation to chemoreceptor control of sleep apnea, description of the apneic threshold, pathophysiology of upper airway closure, novel techniques to measure control of breathing, effect of cerebral blood flow on breathing, effect of opioids on ventilation, effect of heart failure on ventilation, genetic aspects of breathing disorders, age and gender differences, and various therapies are discussed.

• Helps to bridge the gap between straight forward physiology and clinical practice through a range of topics and use of case vignettes
• Explores various aspects of clinical management and control which is beneficial to sleep clinicians, respiratory physiologists, intensivists, trainees, and researchers.
• Distills complex concepts into understandable language and figures, providing helping resource to the clinicians, that transforms a dry topic vis a viz control of ventilation into an exciting understandable ‘clinician’ language.

Dr. Susmita Chowdhuri, M.D., M.S. is a Professor of Internal Medicine at Wayne State University School of Medicine and a Staff Physician and the Section Chief of Sleep Medicine at the John D. Dingell VA Medical Center in Detroit, Michigan.

Dr. M. Safwan Badr, M.D., M.B.A. is a Professor and Chair of Internal Medicine at Wayne State University School of Medicine and a Staff Physician at the John D. Dingell VA Medical Center.

Dr. James A Rowley is a Professor of Medicine and Division Chief of Pulmonary/Critical Care and Sleep mMdicine at Wayne State University School of Medicine in Detroit, Michigan.