SELDIN and GIEBISCH's The Kidney. Physiology and Pathophysiology (2 Volume Set)

Volume 1
I: Epithelial and Nonepithelial Transport and Regulation

1. Epithelial Cell Structure and Polarity
KARLS. MATLIN AND MICHAEL J. CAPLAN

2. Mechanisms of Ion Transport across Cell Membranes
LUIS REUSS AND GUILLERMO A. ALTENBERG

3. Renal Ion-Translocating ATPases
DOMINIQUE ELADARI, UOO HASLER AND ERIC FERAILLE

4. Mechanisms of Water Transport Across Cell Membranes and Epithelia
GUILLERMO A. ALTENBERG AND LUIS REUSS

5. Cell Volume Control
FLORIAN LANG

6. Solute Transport, Energy Consumption, and Production in the Kidney
TAKASHI SEK INE AND HITOSHI ENDOU

7. Electrophysiological Analysis of Transepithelial Transport
HENRY SACKIN AND LAWRENCE G. PALMER

8. Renal Ion Channels, Electrophysiology of Transport, and Channelopathies
JAMES D. STOCKAND

9. Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular WallsC.
CHARLES MICHEL

10. External Balance of Electrolytes and Acids and Alkali
MAN S.OH

11. Renal Cilia Structure, Function, and Physiology
JAY N. PIECZYNSKI AND BRADLEY K. YODER

12. Intercellular Junctions
ALAN S.L. YU, FIONA HANNER AND J ANOS PETI-PETERDI

13. Principles of Cell Signaling
LLOYD CANTLEY

14. Scaffolding Proteins in Transport Regulation
PAUL A. WELLING

15. The Renin–Angiotensin System
THU H. LE, STEVEN D. CROWLEY, SUSAN B. GURLEY AND THOMAS M. COFFMAN

16. Neural Control of Renal Function
EDWARD J. JOHNS AND ULLA C. KOPP

17. Eicosanoids and Renal Function
MATTHEW D. BREYER, RAYMOND C. HARRIS AND RICHARD M. BREYER

18. Extracellular Nucleotides and Renal Function
DAVID G. SHIRLEY, MATTHEW A. BAILEY, SCOTT S.P. WILDMAN, FREDERICK W.K. TAM AND ROBERT J. UNWIN

19. Paracrine Regulation of Renal Function by Dopamine
PEDRO A. JOSE, ROBIN A. FELDER AND GILBERT M. EISNER

II: Structural and Functional Organization of the Kidney

20. Structural Organization of the Mammalian Kidney
WILHELM KRIZ AND BRIGITTE KAISSLING

21. Biophysical Basis of Glomerular Filtration
SCOTT C. THOMSON AND ROLAND C. BLANTZ

22. Glomerular Cell Biology
YOSHIRO MAEZAWA, DAVIDE CIN A AND SUSAN E. QUAGGIN

23. Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion
JURGEN B. SCHNERMANN AND HAYO CASTROP

24. Renal Cortical and Medullary Microcirculations: Structure and Function
THOMAS L. PALLONE AND CHUNHUA CAO

25. Molecular and Cellular Mechanisms of Kidney Development
KEVIN T. BUSH, HIROYUKI SAKURAI AND SANJAY K. NIGAM

26. Molecular and Cellular Mechanisms of Glomerular Capillary Development
JEFFREY H. MINER AND DALE R. ABRAHAMSON

27. Postnatal Renal Development
MICHEL BAUM, JYOTHSNA GATTINENI AND LISA M. SATLIN

28. Renal Hyperplasia and Hypertrophy
PAUL T. BRINKKOETTER, SIAN V. GR IFFIN AND STUART J. SHANKLAND

29. Stem Cells and Generation of New Cells in the Adult Kidney
JUAN A. OLIVER AND QAIS AL-AWQATI

III: Fluid and Electrolyte Regulation and Dysregulation

30. Epithelial Na+ Channels
SHAOHU SHENG, KENNETH R. HALLOWS AND THOMAS R. KLEYMAN

31. Anion Channels
OWEN M. WOODWARD AND WILLIAM B. GUGGINO

32. Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney
GERARDO GAMBA

33. Sodium and Chloride Transport: Proximal Nephron
ALAN M. WEINSTEIN

34. Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct
GERARDO GAMBA, WENHUI WANG AND LAURENT SCHILD

35. Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron
OLIVIER STAUB AND JOHANNES LOFFING

36. Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies
UTE I. SCHOLL AND RICHARD P. LIFTON

37. Natriuretic Hormones
DAVID L. VESELY

38. Pathophysiology of Sodium Retention and Wastage
BIFF F. PALMER, ROBERT J . ALPERN AND DONALD W. SELDIN

39. Physiology and Pathophysiology of Hypertension
JOHN E. HALL, J OEY P. GRANGER AND MICHAEL E. HALL

40. Physiology and Pathophysiology of Diuretic Action
DAVID H. ELLISON41. Aquaporin Water Channels in Mammalian KidneyS0REN NIELSEN, TAE-HWAN KWON, HENRIK DIMKE, MARTIN SKOTT AND J0RGEN FR0KIIER

42. Thirst and Vasopressin
GARY L. ROBERTSON

43. The Urine Concentrating Mechanism and Urea Transporters
JEFF M. SANDS AND HAROLD E. LAYTON

44. Hyponatremia
RICHARD H. STERNS, STEPH EN M. SILVER AND J . KEVIN HIX

45. Hypernatremic States
CHRISTOPHER j. RIVARD, WEI WANG AND LAURENCE CHAN

46. Polyuria and Diabetes Insipidus
DANIEL G. BICHET

47. The Molecular Biology of Renal K+ Channels
WENHUI WANG AND CHOU-LONG HUANG

48. Extrarenal Potassium Metabolism
VAIBHAV SAHNI , ALEKSANDRA GMURCZYK AND ROBERT M. ROSA

49. Regulation of K+ Excretion
GERHARD MALNIC, GERHARD GIEBISCH, SHIGEAKI MUTO, WENHUI WANG, MATTHEW A. BAILEY AND LISA M. SATLIN

50. Physiopathology of Potassium Deficiency
FR ANCESCO TREPICCIONE, MIRIAM ZACCHIA AND GIOVAMBATTISTA CAPASSO

Volume II

51. Clinical Disorders of Hyperkalemia
KAMEL S. KAMEL, SHIH-HUA LIN, SUNG-SEN YANG AND MITCHELL HALPERIN

52. Control of Intracellular pH
MARK 0. BEVENSEE AND WALTER F. BORON

53. SLC4 Sodium-Driven Bicarbonate Transporters
IRA KURTZ

54. The SLC4 Anion Exchanger Gene Family
ANDREW K. STEWART AND SETH L. ALPER

55. Cellular Mechanisms of Renal Tubular Acidification
L. LEE HAMM, ROBERT]. ALPERN AND PATRICIA A. PREISIG

56. Chemoreceptors, Breathing and pH
EUGENE NATTIE

57. Renal Ammonium Ion Production and Excretion
NORMAN P. CURTHOYS

58. Clinical Syndromes of Metabolic Alkalosis
ORSON W. MOE, ROBERT]. ALPERN AND DONALD W. SELDIN

59. Clinical Syndromes of Metabolic Acidosis
RETO KRAPF, DONALD W. SELDIN AND ROBERT]. ALPERN

60. Respiratory Acid–Base Disorders
N ICOLAOS E. MADIAS AND HORACIO ]. ADROGUE

61. Mechanisms and Disorders of Magnesium Metabolism
KARL P. SCHLINGMANN, GARY A. QUAMME AND MARTIN KONRAD

62. Calcium Channels
JOOST G.]. HOENDEROP AND RENE J.M. BINDELS

63. The Calcium-Sensing Receptor
EDWARD M. BROWN , STEVEN C. HEBERT, DANIELA RICCARDI AND J OHN P. GEIBEL

64. Renal Calcium Metabolism
JOSE F. BERNARDO AND PETER A. FRIEDMAN

65. The Hormonal Regulation of Calcium Metabolism
PETER]. TEBBEN AND RAJIV KUMAR

66. Disorders of Calcium Metabolism
CRISTINA DUMITRU AND J OHN WYSOLMERSKI

67. Pathogenesis and Treatment of Nephrolithiasis
FREDRIC L. COE, ANDREW EVAN AND ELAINE WORCESTER

68. Proximal Tubular Handling of Phosphate
HEINl MURER, I AN C. FORSTER, NAT!HERN ANDO AN D JURG BIBER

69. Clinical Disturbances of Phosphate Homeostasis
THERESA]. BERNDT AND RAJ IV KUMAR

70. Glucose Reabsorption in The Kidney
CHARLES S. HUMMEL AND ERNEST M. WRIGHT

71. Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias
SIMON E M.R. CAMARGO, V!CfORIA MAKRIDES, ROBERT KLETA AND FRAN<;::OIS VERREY

72. Organic Anion and Cation Transporters in Renal Elimination of Drugs
GERHARD BURCKHARDT AND HERMANN KOEPSELL

73. Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria
ERIK ILS0 CHRISTENSEN, RIKKE NIELSEN AND HENRIK BIRN

IV: Pathophysiology of Renal Disease

74. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid–Base Disorders
DANIEL BATLLE, SHELDON CHEN AND SYED K. HAQUE

75. Biomarkers for Assessment of Renal Function During Acute Kidney Injury
PRASAD DEVARAJAN

76. Pathophysiology of Acute Kidney Injury
BRUCE A. MOLITORIS AND ASIF SHARFUDDIN

77. Ischemic Renal Disease
WILLIAM L. HENRICH

78. Pathophysiology and Pathogenesis of Diabetic Nephropathy
SHELDON CHEN, CHARBEL KHOURY AND FUAD N. ZIYADEH

79. Renal Failure in Cirrhosis
PERE GINES, ANDRES CARDENAS AND ROBERT W. SCHRIER

80. Autosomal Dominant Polycystic Kidney Disease
STEFAN SOMLO, VICENTE E. TORRES AND MICHAEL J. CAPLAN

81. Renal Physiology and Disease in Pregnancy
MARSHALL D. LINDHEIMER, KIRK P. CONRAD AND S. ANANTH KARUMANCHI

82. Immune and Inflammatory Glomerular Diseases
ANUP MANOHARON, JEFFREY R. SCHELLING, MATTHEW DIAMOND, MOONJA CHUNG-PARK, MICHAEL MADAIO AND JOHN R. SEDOR

83. Immunologic Mechanisms of Vasculitis
JONATHON W. HOMEISTER, J . CHARLES JENNETTE AND RONALD J. FALK

84. Genetic Abnormalities in Glomerular Function
YOAV SEGAL AND CLIFFORD E. KASHTAN

85. Cellular Mechanisms of Drug Nephrotoxicity
ROBERT J AMES WALKER AND ZOLTAN HUBA ENDRE

86. Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease
CLARICE KAZUE FUJIHARA AND ROBERTO ZATZ

87. Role of Proteinuria in the Progression of Renal Disease
MAURO ABBATE, DANIELA MACCON I, GIUSEPPE REMUZZI AND CAR LA ZOJA

88. The Inflammatory Response to Ischemic Acute Renal Injury
CHRISTOPHER Y. LU

89. Catalytic (Labile) Iron in Kidney Disease
MOHAN RAJAPURKAR, RADHAKRISHNA BALIGA AND SUDHIR V. SHAH

90. Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein
BIRUH T. WORKENEH AND WILLIAM E. MITCH

91. Management of Calcium and Bone Disease in Renal Patients
L. DARRYL QUARLES

92. Hematopoiesis and the Kidney
ARM IN KURTZ, ROLAND H. WENGER AND KAI-UWE ECKARDT

93. Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient
BIFF F PALMER

94. Homeostasis of Solute and Water by the Transplanted Kidney
J. HAROLD HELDERMAN, HEIDI SCHAEFER, ANTHONY]. LANGONE AND SIM IN GORAL

95. Renal Disposition of Drugs and Translation to Dosing Strategies

Description

Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a unified and authoritative foundation for understanding normal renal physiology, the mechanisms underlying kidney diseases, and the physiologic principles guiding their diagnosis and management. For nearly three decades, this classic reference has served nephrology researchers, fellows, and clinicians, offering a comprehensive and translational perspective that seamlessly integrates basic science with clinical application.

Guided by four distinguished leaders in nephrology, the book brings together experts across renal research and practice. Readers are led from the structure and function of the healthy kidney, through cellular and molecular pathways of disease development, and into evidence-based approaches for managing renal disorders. This edition remains an indispensable resource, allowing academic, medical, and pharmaceutical professionals to access the most current and reliable information without navigating thousands of individual research articles.

• Presents the most comprehensive, translational source for all aspects of normal renal physiology and the pathophysiology of kidney diseases in a single reference work
• Offers clear, authoritative presentations by leading basic and clinical researchers across all renal disease categories, including fluid and electrolyte disorders, genetic conditions, glomerular diseases, diabetic nephropathy, preeclampsia, dialysis, and transplantation