An Information Technology Framework for Predictive, Preventive and Personalised Medicine. a Use-Case with Hepatocellular Carcinoma

Description

This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepaellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient — functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes.

Contents

Preface

Chapter 1 Introduction
Leonard Berliner and Heinz U. Lemke

Chapter 2 The Digital Patient Model and Model Guided Therapy
Leonard Berliner and Heinz U. Lemke

Chapter 3 Hepaellular Carcinoma and Patient Assessment
Smruti Mohanty, Sid Verma, David Dosik, Hesham Hazin and Leonard Berliner

Chapter 4 Imaging in Hepaellular Carcinoma: Radiologic Assessment
Irene Bargellini, Valentina Battaglia, Davide Caramella and Carlo Bartolozzi

Chapter 5 Imaging in Hepaellular Carcinoma: PET/CT
Giuseppe Esposito

Chapter 6 Personalized Chemotherapy for Hepaellular Carcinoma
Hesham Hazin and David Dosik

Chapter 7 Surgical Treatment for Hepaellular Carcinoma Smruti Mohanty, Leonard Berliner and Syed Shah

Chapter 8 Minimally Invasive Therapies for Hepaellular Cancer: Ablation Technologies
Paul Morrison and Eric vanSonnenberg

Chapter 9 Minimally Invasive Therapies for Hepaellular Cancer: Ablation Therapies
Eric vanSonnenberg and Leonard Berliner

Chapter 10 Minimally Invasive Therapies for Hepaellular Cancer: Catheter-Directed Therapies
Leonard Berliner and Smruti Mohanty

Chapter 11 Radiation Oncology in the Treatment of Hepaellular Carcinoma
Hani Ashamalla and Malcom D. Mattes

Chapter 12 Design of an IT System for Hepaellular Carcinoma
Leonard Berliner and Heinz U. Lemke

Chapter 13 Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepaellular Carcinoma
Leonard Berliner, Heinz U. Lemke, Hani Ashamalla and Smruti Moha