Cancer Metabolism. Molecular Mechanisms and Therapeutic Strategies

1. Introduction to Cancer Metabolism

   • Gomathi Mohan, Mukesh Meena, Manzer H. Siddiqui, Gaurav Raturi, Pracheta Janmeda, Priya Chaudhary

   Pages 1-20

2. The Warburg Effect and Aerobic Glycolysis in Tumors

   • Bhupender Nehra, Sourabh Suthar, Rishabh Kasnia, Sunaina Demiwal, Mohini Mondal, Himanshu Sharma et al.

   Pages 21-43

3. Glutamine Metabolism: Role in Cancer Cell Proliferation and Survival

   • Aganta Chakraborty, Sanket Pramanik, Shrabasti Mullick, Rajarshi Nath, Mohini Mondal, Radheshyam Pal et al.

   Pages 45-78

4. Lipid Metabolism and Oncogenesis

   • Mirunalini Gobinath, Pratik Phalke, Parikshit Roychowdhury, Alberto Ouro Villasante, Naina Mohamed Pakkir Maideen

   Pages 79-94

5. The Role of Oxidative Stress and Redox Regulation in Cancer

   • Nahid Nafissi, Pedram Fadavi, Farzad Taghizadeh-Hesary

   Pages 95-107

6. Mitochondrial Metabolism and Dynamics in Cancer Cells

   • Pedram Fadavi, Farzad Taghizadeh-Hesary

   Pages 109-120

7. Metabolic Cross Talk in the Tumor Microenvironment

   • Chinmay Das, Somya Ranjan Dash, Biswajit Das, Subhajit Chatterjee, Tithi Parija

   Pages 121-154

8. Metabolic Reprogramming in Cancer Stem Cells

   • Gaurav Ranjan, Srijani Dasgupta, Uttam Kumar Mishra, Priyashree Sunita, Shakti Prasad Pattanayak

   Pages 155-174

9. Targeting Metabolism in Cancer Therapy: Inhibitors and Approaches

   • Bhabani Shankar Nayak, Bangmayee Dash, Sisir Nandi, Nebojša Pavlović, Mohamed Dkhi

   Pages 175-191

10. Biomarkers of Cancer Metabolism and Therapeutic Response

    • Hamid Tanzadehpanah, Ali Ahmadizad Firouzjaei, Nafiseh Izadi, Mona Mansourian, Amir Hossein Esfandiari, Khatere Mokhtari et al.

    Pages 193-220

11. Cancer and Immune Cells: A Metabolic Battle in the Tumor Microenvironment

    • Sam Pournezhad, Ramyar Azar, Farzad Taghizadeh-Hesary

    Pages 221-235

12. Tools and Technologies for Studying Cancer Metabolism

    • Ayush Madan, Subhajit Mandal, Soukat Chandra, Joy Das, Biplab Debnath

    Pages 237-247

13. Clinical Trials and Translational Advances in Metabolic Targeting

    • Hariharan Thirumalai Vengateswaran, Mohammad Habeeb, Huay Woon You, Ciniraj Raveendran

    Pages 249-266

14. Back Matter

    Pages 267-275

• Explores the emerging field of glutamine metabolism as a therapeutic target in diverse cancer types
• Comprehensive exploration of cancer metabolism
• Broad topic for cancer biologists , metabolic researchers, clinical oncologists, and pharmaceutical developers

Cancer cells survive and thrive by radically reshaping the way they use energy, nutrients, and metabolic pathways. This book offers a clear and comprehensive exploration of this rapidly evolving field, revealing how tumors rewire core biochemical processes to sustain proliferation, evade cell death, and adapt to the pressures of the tumor microenvironment. From foundational concepts to cutting‑edge discoveries, the book provides an essential entry point for understanding the metabolic logic that underlies cancer progression.

Central to this volume is an in‑depth examination of glutamine metabolism. Alongside this focus, the book extends broadly across the metabolic landscape, covering glycolysis, lipid synthesis and utilization, redox regulation, mitochondrial dynamics, and metabolic communication between cancer cells and their surrounding stromal and immune partners. Each chapter distills mechanistic insight while emphasizing translational relevance, bridging basic science with the latest therapeutic strategies and clinical applications.

Written by leading researchers and clinicians, this book serves as a valuable resource for scientists, oncologists, and drug developers seeking to understand and target the metabolic vulnerabilities of cancer. Whether exploring metabolic reprogramming in cancer stem cells, evaluating biomarkers of metabolic states, or assessing emerging therapies and clinical trial data, readers will gain an integrated perspective on how metabolism shapes tumor behavior and influences treatment outcomes. This is an indispensable guide for anyone committed to advancing cancer research, improving patient care, and translating metabolic insights into meaningful therapeutic advances.