Radiobiology Self-Assessment Guide

Description

Radiobiology Self-Assessment Guide--a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide--is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and rationales along withreference citations for source information.

The guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination. Aspects of basic radiobiology covered includefundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. Modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included. Focused and authoritative, this must-have review provides the expertise of faculty from the Department of Radiation Oncology at the Cleveland Clinic TaussigCancer Institute and Lerner Research Institute.

Key Features:

• Provides a comprehensive study guide for the Radiation and Cancer Biology portion to the Radiation Oncology Board Exam
• Includes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like review
• Includes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agents
• Content provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology residents

Contents

Contributors 

Preface

1. Interaction of Radiation With Matter
John F. Greskovich, Jr., Mihir Naik, and Marc Apple
 2. Cell Survival Curves and Cell Death
Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan
3. DNA, Chromosome and Chromatid Damage, Repair, and Measurement
Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan
4. Radiosensitivity and the Dose-Rate Effect
Brian D. Yard and Mohamed E. Abazeed
5. Radiation Damage Repair and Models for Normal Tissues
Aditya Juloori, Choamei Xiang, Michael A. Weller, and Jennifer S. Yu
6. Hypoxia, Oxygen, Reoxygenation, and Angiogenesis
Xingjiang Yu, Jennifer S. Yu, and Eli Bar
7. Linear Energy Transfer and Relative Biological Effectiveness
Yvonne Pham and Chirag Shah
8. Assays for Cell, Tissue, and Solid Tumors
C. Marc Leyrer, Ehsan H. Balagamwala, and Camille Berriochoa
9. Molecular Techniques, Assay Systems  and Signaling in Radiobiology
Kailin Yang and Jennifer S. Yu
10. Biology of Cancer
Kailin Yang and Jennifer S. Yu
11. Model Tumor Systems and Predictive Assays
C. Marc Leyrer, Camille Berriochoa, and Ehsan H. Balagamwala
12. Cell Kinetics
Matthew C. Ward and Richard Blake Ross
13. Factors Influencing Tumor Control and Complications
Daesung Lee
14. Impact of Time, Dose, and Fractionation in Radiation Oncology
Daesung Lee
15. Effects of Total Body Irradiation
Sudha Amarnath
16. Radiation Sensitizers, Radioprotectors, and Bioreductive Drugs
Aditya Juloori and Michael A. Weller
17. Radiation Carcinogenesis
Bindu V. Manyam and Michael A. Weller
18. Effects of Radiation on Hereditary Damage, Mutations, and Chromosome Aberrations
Camille Berriochoa, C. Marc Leyrer, and Anthony Mastroianni
19. Effects of Radiation on the Embryo and Fetus
Yvonne Pham and Steven Oh
20. Doses and Risks in Nonradiation Oncology Subspecialties
Frank Dong, Kevin Wunderle, and Salim Balik
21. Radiation Protection
Taoran Cui and Peng Qi
22. Alternative Radiation Therapy Modalities
Susan Kost and Andrew Godley
23. Brachytherapy and Stereotactic Radiosurgery
Sudha Amarnath
24. Gene Therapy
HyeonJoo Cheon
25. Chemotherapy and Targeted Agents
Nikhil Joshi and Neil Woody
26. Hyperthermia
Sharvari Dharmaiah, Vinay Rao, and Jennifer S. Yu
27. Stem Cells
Haidong Huang and Jennifer S. Yu
28. Immunotherapy
Nikhil Joshi and Neil Woody
29. Radiogenomics
Mohamed E. Abazeed
Index