Neurodegeneration

Description

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.

• Presents a clinically oriented guide to the diseases caused by neurodegeneration
• Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually
• Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases
• Edited by globally leading authorities on the subject, and written by expert contributing authors

Contents

List of Contributors
Preface
Dedication

Chapter 1: Pathology of Brain Aging
Janna H. Neltner and Peter T. Nelson

Chapter 2: Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies
Michel Goedert

Chapter 3: Prion Degeneration
James A. Mastrianni

Chapter 4: Excitotoxicity
Mark P. Mattson

Chapter 5: Aetiology and Pathogenesis of Parkinson Disease
Ruth-Mary deSouza and Anthony H.V. Schapira

Chapter 6: Parkinson’s Disease: Treatment Options – Surgical Therapy
Travis S. Tierney and Andres M. Lozano

Chapter 7: Multiple System Atrophy (MSA): Clinical, Genetics and Neuropathology
Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden and Owen A. Ross

Chapter 8: Progressive Supranuclear Palsy
Huw R. Morris

Chapter 9: Dementia with Lewy Bodies
Rodolfo Savica and David S. Knopman

Chapter 10: Corticobasal Degeneration
Keith A. Josephs

Chapter 11: Alzheimer’s Disease
Qurat ul Ain Khan and Neill R. Graff-Radford

Chapter 12: Frontotemporal Dementia
Christian Wider, Barbara Jasinska-Myga and Zbigniew K. Wszolek

Chapter 13: Prion Diseases and Other Rapidly Progressive Dementias
Eric Eggenberger and Daniel L. Murman

Chapter 14: ALS and PLS
Kevin B. Boylan, Mark A. Ross and Eric J. Sorenson

Chapter 15: Hereditary Spastic Paraplegia
Pawel P. Liberski and Craig Blackstone

Chapter 16: Spinal Muscular Atrophy
Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles and Charlotte J. Sumner

Chapter 17: Spinal and Bulbar Muscular Atrophy (Kennedy Disease)
Erich Peter Bosch

Chapter 18: Optic Neuropathies
Desmond Kidd

Chapter 19: Peripheral Nerve Neuropathies Including CMT Disease
Amelie Pandraud and Henry Houlden

Chapter 20: Axonal Loss and Neurodegeneration in Multiple Sclerosis
Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda and Bruce D. Trapp

Chapter 21: Neurodegeneration: Huntington’s Disease and Other Choreas
Salman Haider, Edward Wild and Sarah J. Tabrizi

Chapter 22: Spinocerebellar Ataxias
H. Brent Clark and Harry T. Orr

Chapter 23: Ataxia Telangiectasia
Malcolm Taylor

Chapter 24: Niemann-Pick Disease
Marc C. Patterson

Chapter 25: X-linked Adrenoleukodystrophy
Deborah L. Renaud

Chapter 26: Neurodegeneration with Brain Iron Accumulation, Wilson Disease, Manganism
Alisdair McNeill

Index

About the Editors

Professor Anthony Schapira is Professor of Neurological Science and Head of the Department of Clinical Neuroscience at the UCL Institute of Neurology, London, UK and Chairman of Clinical Neurosciences Specialties.

Zbigniew Wszolek, MD, is Professor of Neurology in the Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA

Ted M.Dawson, MD, PhD, is Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases and Scientific
Director in the Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Professor Nicholas Wood is Research Director of the UCL Institute of Genetics and Galton Professor of Genetics at UCL National Hospital for Neurology and Neurosurgery, Institute of Neurology, London, UK.