KUMAR and CLARK's Cases in Clinical Medicine

1 Infectious Diseases
Pyrexia of unknown origin (PUO)
Septicaemia
Meningococcal meningitis and septicaemia
Brain abscess
Pseudomembranous colitis
Food poisoning
Typhoid
The returning traveller
Shingles
Epstein–Barr virus

2 Sexually Transmitted Infections
HIV/AIDS
Vaginal discharge
Urethral discharge and genital ulcers/warts

3 Nutrition
Feeding the patient

4 Gastroenterology
Vomiting
Hiccups
Weight loss
Dysphagia
Constipation
Diarrhoea
Abdominal pain
Gastro-oesophageal reflux disease (GORD)
Barrett’s oesophagus
Peptic ulcer disease
Rectal bleeding
Family history of colon cancer
Functional bowel disease

5 Liver and Biliary Tract Disorders
Abnormal liver biochemistry
Jaundice
Acute liver disease
Ascites
Haematemesis and melaena
Non-alcoholic fatty liver disease
Liver failure
Excess alcohol use
Cholecystitis
Acute cholangitis

6 Haematology and Oncology
Microcytic and macrocytic anaemia
Iron deficiency anaemia
Haemolytic anaemia
Elevated haemoglobin (polycythaemia)
Elevated white blood cell count
Elevated platelet count
Platelet disorders
Bleeding disorders
Disseminated intravascular coagulation (DIC)
Thrombosis
Thrombosis and the anti-phospholipid syndrome
Sickle-cell disease
Types of sickle-cell disease
Glucose-6-phosphate dehydrogenase deficiency
Splenomegaly, splenectomy and hyposplenism
Blood transfusion
Haematological oncology
Anaemia in rheumatoid arthritis
Anaemia in cancer
Infection/sepsis

7 Care of the Elderly and Palliative care
Blackouts
Falls in the elderly
Benign paroxysmal positional vertigo
Delirium
Dementia
Depression
Non-specific presentation of illness in the elderly
Appropriate assessment scales
Stroke
Heart disease in the elderly
Transient ischaemic attack
Hypothermia
Pressure ulcers
Urinary tract infection and incontinence
Arteritis
Acute hot joint [consider removal - does not add much not already covered]
Parkinson’s disease
Drug treatment in older people/drug treatment as a cause of illness and admission to hospital
Drugs as a cause of illness and delayed discharge
Do not attempt resuscitation (DNAR) decision-making
Palliative care symptom management

8 Rheumatology
Osteoarthritis (OA)
Rheumatoid arthritis (RA)
SLE and vasculitis
Acute autoimmune rheumatic disease
Reactive arthritis
Crystal arthritis
Polymyalgia rheumatica/giant cell arteritis
Polymyositis and dermatomyositis
Acute back pain
Severe back pain/osteoporosis
Osteomyelitis
Septic arthritis

9 Kidney and Urinary Tract Disease
Presentation of kidney and urinary tract disease
Fluid balance and electrolytes: assessing fluid status
Fluid balance and electrolytes: sodium problems
Patient stopped passing urine
Acute heart failure
Hyperkalaemia
The acidotic patient
Acute kidney injury
Chronic kidney disease
Multisystem vasculitis/acute glomerulonephritis
Intercurrent illness in dialysis and transplant patients
Nephrotic syndrome
Haematuria without albuminuria
Urinary tract infection (UTI)
Renal and ureteric colic

10 Cardiology
Syncope
A clinical approach to patients with tachycardia
Atrial fibrillation
Bradycardia and pacing
Cardiac arrest and basic life support
Chest pain and acute coronary syndromes
Thrombolysis
Acute myocardial ischaemia
Cardiogenic shock
Right ventricular infarction
Heart failure following an MI
Post-infarction arrhythmias and heart block
Myocardial infarction – secondary prevention
Heart failure recognition and acute management
Pericardial disease [include tamponade, pericarditis]
Valvular heart disease
Infective endocarditis
Pulmonary hypertension
Cardiomyopathies
Hypertension (HT)
The swollen/painful leg

11 Respiratory Disorders
Acute breathlessness
Cough
Breathlessness and wheeze
Hyperventilation
Haemoptysis
Chest pain
Bronchiolitis [add other childhood differentials]
Respiratory failure
COPD – acute exacerbation
Pneumonia
COVID
Lung abscess
Tuberculosis
Pleural effusion
Pulmonary embolism
Pneumothorax
Carcinoma of the bronchus
Sarcoidosis

12 ITU
Shock
Anaphylaxis
Acute lung injury/Acute Respiratory Distress Syndrome (ARDS)

13 Poisoning
Self-poisoning
Paracetamol (acetaminophen) poisoning
Salicylate overdose
Cocaine
Gammahydroxybutyric acid (GHB)
Insect stings and bites

14 Endocrinology and Diabetes
Diabetes mellitus
Diabetic ketoacidosis (DKA)
Hyperosmolar hyperglycaemic state
Hypoglycaemic coma
Sick diabetic patient
Management of new type 2 diabetic presenting for surgery
Urgent surgery in patients with diabetes
Diabetic foot
Diabetes in pregnancy
Cushing’s syndrome
Hyperthyroidism
Amiodarone and thyroid function
Hypothyroidism
Addison’s disease
Patients on steroids for surgery
Metabolic bone diseases (add osteomalacia, Paget’s disease of bone – inc. summary data interpretation of)
Hypercalcaemia
Severe hypercalcaemia
Hypocalcaemia
Phaeochromocytoma (catecholamine crisis)
Hypopituitarism
Diabetes insipidus
Syndrome of inappropriate anti-diuretic hormone (SIADH)

15 Neurology
Diplopia
Loss of vision
Ophthalmology
Bell’s palsy
Vertigo
Stroke
Subdural haemorrhage
Encephalitis
Meningitis [moved position]
Traumatic brain injury
Severe brain injury
Fits and faints
Headaches
Falls [moved position]
Difficulty walking [moved position]
Movement disorders [moved position]
Parkinson’s disease [moved position]
Multiple sclerosis (MS) [moved position]
Guillain–Barré syndrome
Spinal cord compression

16 Psychiatry
Delirium
Drugs and poisons as causes of delirium
Dementia
Delirium tremens (DT)
Depression
Suicide and deliberate self-harm (DSH)
Acute anxiety
Opiate dependence
ADHD
The disturbed patient

17 Dermatology
A swollen red leg
Generalised rash or eruption [moved position]
Pruritus [moved position]
Eczema
Psoraisis
Urticaria and angio-oedema
Skin nodules [Case]
- Case of Malignant melanoma
- Differentials BCC, SCC, warts, dermatofibroma, pyogenic granuloma
Cutaneous adverse drug reactions (ADR)
Sun-induced rash [moved position]
Erythema nodosum [moved position]HIV and the skin