Diagnostic Pathology: Soft Tissue Tumors

SECTION 1: SOFT TISSUE INTRODUCTION

INTRODUCTION AND OVERVIEW

4 Gross Examination

Matthew R. Lindberg, MD

6 Grading and Staging

Matthew R. Lindberg, MD

ANCILLARY TECHNIQUES

12 Soft Tissue Immunohistochemistry

Matthew R. Lindberg, MD

18 Molecular Features of Soft Tissue Tumors

Matthew R. Lindberg, MD

SECTION 2: DIAGNOSTIC APPROACH TO SOFT TISSUE TUMORS

OVERVIEW

22 Biopsy and Resection of Soft Tissue Tumors

Matthew R. Lindberg, MD

CLINICAL APPROACH

26 Age- and Location-Based Approach to Diagnosis

Matthew R. Lindberg, MD

HISTOLOGIC APPROACH

28 Pattern-Based Approach to Diagnosis

Matthew R. Lindberg, MD

36 Feature-Based Approach to Diagnosis

Matthew R. Lindberg, MD

SECTION 3: TUMORS OF ADIPOSE TISSUE

BENIGN

46 Lipoma

Matthew R. Lindberg, MD

52 Lipomatosis of Nerve

Michella Whisman, MD and Jerad M. Gardner, MD

54 Synovial Lipomatosis

Matthew R. Lindberg, MD

56 Angiolipoma

Michella Whisman, MD and Jerad M. Gardner, MD

60 Spindle Cell/Pleomorphic Lipoma

Matthew R. Lindberg, MD

66 Chondroid Lipoma

Matthew R. Lindberg, MD

70 Myolipoma

Michella Whisman, MD and Jerad M. Gardner, MD

74 Hibernoma

Matthew R. Lindberg, MD

78 Myelolipoma

Matthew R. Lindberg, MD

80 Lipoblastoma

Matthew R. Lindberg, MD

84 Atypical Spindle Cell/Pleomorphic Lipomatous Tumor

Matthew R. Lindberg, MD

88 Lipoblastoma-Like Tumor of Vulva

Matthew R. Lindberg, MD

INTERMEDIATE, LOCALLY AGGRESSIVE

92 Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma

Matthew R. Lindberg, MD

MALIGNANT

98 Dedifferentiated Liposarcoma

Matthew R. Lindberg, MD

106 Myxoid Liposarcoma

Matthew R. Lindberg, MD

112 Pleomorphic Liposarcoma

Matthew R. Lindberg, MD

118 Myxoid Pleomorphic Liposarcoma

Matthew R. Lindberg, MD

SECTION 4: FIBROBLASTIC/MYOFIBROBLASTIC LESIONS

BENIGN

124 Nodular Fasciitis

Matthew R. Lindberg, MD

130 Proliferative Fasciitis/Myositis

Matthew R. Lindberg, MD

134 Ischemic Fasciitis

Matthew R. Lindberg, MD

136 Myositis Ossificans

Matthew R. Lindberg, MD

140 Fibroosseous Pseudotumor of Digits

David Lucas, MD and Elizabeth A. Montgomery, MD

144 Fibroma of Tendon Sheath

David Lucas, MD

150 Desmoplastic Fibroblastoma

David Cassarino, MD, PhD and Khin Thway, MD, FRCPath

152 Elastofibroma

Matthew R. Lindberg, MD

154 Angiofibroma of Soft Tissue

Matthew R. Lindberg, MD 158 Mammary-Type Myofibroblastoma

Matthew R. Lindberg, MD

162 Plexiform Myofibroblastoma

Matthew R. Lindberg, MD

166 Intranodal Palisaded Myofibroblastoma

Matthew R. Lindberg, MD

170 Pleomorphic Fibroma

David Cassarino, MD, PhD

172 Dermatomyofibroma

David Cassarino, MD, PhD

174 Fibroblastic Connective Tissue Nevus

Matthew R. Lindberg, MD

176 Storiform Collagenoma

David Cassarino, MD, PhD

178 Keloid

David Cassarino, MD, PhD

180 Nuchal-Type Fibroma

Matthew R. Lindberg, MD

INTERMEDIATE (LOCALLY AGGRESSIVE)

182 Palmar/Plantar Fibromatosis

Matthew R. Lindberg, MD

184 Desmoid-Type Fibromatosis

Matthew R. Lindberg, MD

190 EWSR1::SMAD3 Fibroblastic Tumor

Matthew R. Lindberg, MD

INTERMEDIATE (RARELY METASTASIZING)

194 Dermatofibrosarcoma Protuberans

Matthew R. Lindberg, MD

204 Solitary Fibrous Tumor

Matthew R. Lindberg, MD

212 Low-Grade Myofibroblastic Sarcoma

Matthew R. Lindberg, MD

216 Inflammatory Myofibroblastic Tumor

Matthew R. Lindberg, MD

222 Myxoinflammatory Fibroblastic Sarcoma

Matthew R. Lindberg, MD

230 Superficial CD34(+) Fibroblastic Tumor

Matthew R. Lindberg, MD

MALIGNANT

234 Adult-Type Fibrosarcoma

Michella Whisman, MD and Jerad M. Gardner, MD

236 Myxofibrosarcoma

Matthew R. Lindberg, MD

242 Low-Grade Fibromyxoid Sarcoma

Matthew R. Lindberg, MD

252 Sclerosing Epithelioid Fibrosarcoma

Matthew R. Lindberg, MD

258 Epithelioid Inflammatory Myofibroblastic Sarcoma

Matthew R. Lindberg, MD

SECTION 5: PEDIATRIC FIBROBLASTIC/MYOFIBROBLASTIC TUMORS

BENIGN

264 Fibrous Hamartoma of Infancy

Matthew R. Lindberg, MD

268 Calcifying Aponeurotic Fibroma

Matthew R. Lindberg, MD

272 Calcifying Fibrous Tumor

Michella Whisman, MD, Kandi Stallings-Archer, MD, and Elizabeth A. Montgomery, MD

274 Inclusion Body Fibromatosis

Matthew R. Lindberg, MD

276 Hyaline Fibromatosis Syndrome

Michella Whisman, MD, Elizabeth A. Montgomery, MD, and Cyril Fisher, MD, DSc, FRCPath

278 Fibromatosis Colli

Michella Whisman, MD, Kandi Stallings-Archer, MD, and Cyril Fisher, MD, DSc, FRCPath

280 Gardner Fibroma

Michella Whisman, MD and Jerad M. Gardner, MD

INTERMEDIATE (LOCALLY AGGRESSIVE)

282 Lipofibromatosis

Michella Whisman, MD, Kandi Stallings-

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the wide range of often difficult-to-diagnose variants and subtypes in soft tissue tumors, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Soft Tissue Tumors is a visually stunning, one-stop resource for every practicing pathologist, oncologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

Matthew R Lindberg, MD, Director, Soft Tissue Pathology Division, Associate Professor of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas