Diagnostic Pathology: Genitourinary

Kidney Tumors and Tumor-Like Conditions

Introduction and Overview

Introduction to Renal Cell Tumors

Classification of Kidney Tumors and Tumor-Like Lesions

Familial Cancer Syndromes

von Hippel-Lindau Syndrome

Birt-Hogg-Dubé Syndrome

Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome

Tuberous Sclerosis Complex

Succinate Dehydrogenase Complex Deficiency Syndrome

Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes

Nonneoplastic Lesions

Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia

Renal Cell Tumors, Benign

Papillary Adenoma

Renal Oncocytoma

Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Multilocular Cystic Clear Cell Renal Cell Neoplasm of Low Malignant Potential

Clear Cell Renal Cancers With Fibromyomatous Stroma, Including *ELOC*/*TCEB1*-Mutated Renal Cell Carcinoma

Clear Cell Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma

Chromophobe Renal Cell Carcinoma

Collecting Duct Carcinoma

Renal Medullary Carcinoma and Unclassified Carcinomas With Medullary Phenotype

MiTF/TFE Family Translocation-Associated Carcinoma

Mucinous Tubular and Spindle Cell Carcinoma

Tubulocystic Carcinoma

Thyroid-Like Follicular Carcinoma of Kidney

Acquired Cystic Disease-Associated Renal Cell Carcinoma

Fumarate Hydratase-Deficient Renal Cell Carcinoma

*ALK* Rearrangement-Associated Renal Cell Carcinoma

Eosinophilic Solid and Cystic Renal Cell Carcinoma

Eosinophilic Tumors With Somatic *TSC*/*MTOR* Mutations

Subsequent 2nd Tumors

Renal Cell Carcinoma, Unclassified

Metanephric Tumors

Metanephric Adenoma

Metanephric Tumors Other Than Metanephric Adenoma

Nephroblastic Tumors

Nephrogenic Rests

Nephroblastoma (Wilms Tumor)

Cystic Partially Differentiated Nephroblastoma

Mesenchymal Tumors

Angiomyolipoma

Epithelioid Angiomyolipoma

Congenital Mesoblastic Nephroma

Clear Cell Sarcoma of Kidney

Malignant Rhabdoid Tumor

Mixed Mesenchymal and Epithelial Tumors

Mixed Epithelial and Stromal Tumor (MEST) Family Tumors and Pediatric Cystic Nephroma

Synovial Sarcoma

Neuroendocrine Tumors

Well-Differentiated Neuroendocrine Tumor (Carcinoid) and High-Grade Neuroendocrine Carcinoma

Primitive Neuroectodermal Tumor

Hematopoietic Tumors

Hematopoietic Tumors

Metastatic and Other Tumors

Juxtaglomerular Cell Tumor (Reninoma)

Renomedullary Interstitial Cell Tumor

Other Rare Tumors

Metastatic Tumors

Immunohistochemical Profiles for Tumors Involving Kidney

Immunohistochemistry, Kidney

Urinary Tract

Introduction and Overview

Classification of Bladder Tumors and Tumor-Like Lesions

Microscopic Anatomy

Microscopic Anatomy of Urinary Bladder

Microscopic Anatomy of Urethra

Microscopic Anatomy of Ureter

Microscopic Anatomy of Renal Pelvis

Nonneoplastic Lesions of Urinary Tract

Overview of Cystitis

Polypoid Cystitis

Malakoplakia

Schistosomiasis

von Brunn Nests

Nephrogenic Adenoma (Metaplasia)

Fibroepithelial Polyp

Prostatic-Type Polyp (Ectopic Prostate)

Amyloidosis

Müllerian Lesions

Pseudocarcinomatous Hyperplasia

Hamartoma

Urothelial Neoplasms, General

Overview of Urinary Bladder Neoplasms

Flat Urothelial Lesions

Urothelial Carcinoma In Situ

Flat Urothelial Lesions Other Than Carcinoma In Situ

Urothelial Neoplasms, Noninvasive

Urothelial Proliferation of Unknown Malignant Potential

Urothelial Papilloma

Papillary Urothelial Neoplasm of Low Malignant Potential

Low-Grade Papillary Urothelial Carcinoma

High-Grade Papillary Urothelial Carcinoma

Inverted Urothelial Neoplasia

Urothelial Neoplasms, Invasive

Invasive Urothelial Carcinoma

Urothelial Carcinoma, Variants and Divergent Differentiation

Glandular Lesions

Cystitis Cystica et Glandularis

Villous Adenoma

Invasive Adenocarcinoma

Clear Cell Adenocarcinoma

Squamous Lesions

Squamous Proliferations Other Than Carcinoma

Invasive Squamous Cell Carcinoma

Mesenchymal Lesions

Myofibroblastic Proliferations

Smooth Muscle Tumors

Rhabdomyosarcoma

Other Mesenchymal Tumors

Other Tumors of Urinary Bladder

Paraganglioma

Metastatic/Secondary Involvement of Bladder

Diverticula of Urinary Tract

Diverticula

Diverticular-Associated Neoplasia

Urethra

Inflammatory Lesions of Urethra

Carcinoma of Urethra

Other Tumors and Tumor-Like Lesions of Urethra

Ureter

Urothelial Carcinoma of Ureter

Other Tumors and Tumor-Like Lesions of Ureter

Renal Pelvis

Urothelial Carcinoma of Renal Pelvis

Other Tumors and Tumor-Like Lesions of Renal Pelvis

Urachus

Urachal Remnants

Tumors of Urachus

Immunohistochemical Profiles for Tumors Involving Urinary Bladder

Immunohistochemistry, Urinary Tract

Prostate Gland and Seminal Vesicle

Introduction and Overview

Classification of Prostate Tumors and Tumor-Like Lesions

General Concepts, Prostate

Microanatomy and Zonal Variations

Imaging Considerations for Pathologists

Nonneoplastic Lesions

Prostatitis

Prostate Hyperplasia

Adenosis

Atrophy and Its Variants

Hyperplasia of Mesonephric Remnants

Verumontanum Mucosal Gland Hyperplasia

Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra

Putative Premalignant Lesions and Lesions Falling Short of Malignant Diagnosis

Prostatic Intraepithelial Neoplasia

Prostate Neoplasms

General Concepts, Prostate Carcinoma

Acinar Adenocarcinoma

Acinar Adenocarcinoma Variants

Atypical Small Acinar Proliferations

Intraductal Proliferations and Ductal Carcinoma

Ductal Adenocarcinoma

Urothelial Carcinoma Involving Prostate Gland

Prostate Carcinoma With Neuroendocrine Differentiation

Basal Cell Carcinoma

Sarcomatoid Carcinoma of Prostate

Carcinomas With Squamous Differentiation

Cystic Epithelial Tumors of Prostate

Stromal Tumors

Mesenchymal Tumors of Prostate

Melanocytic Lesions of Prostate

Hematopoietic Neoplasms of Prostate

Secondary Tumors of Prostate

Tumors of Seminal Vesicle

Mixed Epithelial and Stromal Tumor

Seminal Vesicle Adenocarcinoma

Immunohistochemical Profiles for Tumors and Tumor-Like Lesions Involving Prostate Gland

Immunohistochemistry, Prostate

Testis and Paratesticular Structures

Introduction and Overview

Classification of Testis and Paratestis Tumors and Tumor-Like Lesions

Nonneoplastic Lesions

Cryptorchidism

Sertoli Cell-Only Syndrome

Nontuberculous Infections

Nonspecific Granulomatous Orchitis

Tuberculous Epididymo-Orchitis

Germ Cell Tumors

General Concepts, Germ Cell Tumors

Germ Cell Tumors Related to Germ Cell Neoplasia In Situ

Germ Cell Neoplasia In Situ

Seminoma

Intratubular Seminoma

Intratubular Embryonal Carcinoma

Embryonal Carcinoma

Yolk Sac Tumor

Choriocarcinoma and Other Trophoblastic Tumors

Postpubertal-Type Teratoma

Mixed Germ Cell Tumors

Somatic-Type Malignancy in Germ Cell Tumor

Burnt-Out (Regressed) Germ Cell Tumor

Germ Cell Tumors Unrelated to Germ Cell Neoplasia In Situ

Spermatocytic Tumor

Pediatric Germ Cell Tumor, General Concepts

Prepubertal-Type Teratoma

Yolk Sac Tumor, Prepubertal Type

Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type

Well-Differentiated Neuroendocrine Tumor (Monodermal Teratoma)

Sex Cord-/Gonadal Stromal Tumors

General Concepts, Sex Cord-/Gonadal Stromal Tumors

Leydig Cell Tumors

Sertoli Cell Tumors

Large Cell Calcifying Sertoli Cell Tumor

Intratubular Large Cell Hyalinizing Sertoli Cell Tumor

Granulosa Cell Tumor

Juvenile Granulosa Cell Tumor

Fibroma-Thecoma

Testicular Tumor of Adrenogenital Syndrome

Sex Cord-Stromal Tumor, Mixed/Unclassified

Gonadoblastoma

Hematopoietic Tumors

Lymphoma/Leukemia/Plasmacytoma

Tumors of Paratesticular Structures

Adenomatoid Tumor

Malignant Mesothelioma

Adenocarcinoma of Rete Testis/Epididymis

Epididymal Tumors

Ovarian Epithelial-Type Tumors

Liposarcoma

Melanotic Neuroectodermal Tumor

Rhabdomyosarcoma

Other Sarcomas

Metastatic Tumors, Testis and Paratesticular Structures

Metastatic Tumors, Testis and Paratesticular Structures

Immunohistochemical Profiles for Tumors Involving Testis and Paratesticular Structures

Immunohistochemistry, Testis

Penis and Scrotum

Frequent Lesions of Uncertain Relationship to Penile Neoplasia

Condyloma

Lichen Sclerosus et Atrophicus

Squamous Hyperplasia

Lipogranuloma

Scrotal Calcinosis

Penile Intraepithelial Neoplasia

Penile Intraepithelial Neoplasia

Primary Epithelial Tumors

General Concepts, Squamous Cell Carcinoma (Including Staging and Molecular Pathology)

Squamous Cell Carcinoma, Usual Type

Variants of Squamous Cell Carcinoma

Basaloid Squamous Cell Carcinoma

Basaloid Squamous Cell Carcinoma, Papillary Variant

Warty (Condylomatous) Squamous Cell Carcinoma

Warty-Basaloid Squamous Cell Carcinoma

Verrucous Squamous Cell Carcinoma

Papillary Squamous Cell Carcinoma, Not Otherwise Specified

Pseudoglandular Squamous Cell Carcinoma

Pseudohyperplastic Squamous Cell Carcinoma

Cuniculatum Squamous Cell Carcinoma

Sarcomatoid Squamous Cell Carcinoma

Mixed Squamous Cell Carcinoma

Undifferentiated to Poorly Differentiated Squamous Cell Carcinomas With Prominent Inflammatory Infiltrate

Clear Cell Carcinoma

HPV- and Non-HPV-Related Tumors

Overview of HPV- and Non-HPV-Related Tumors

Other Neoplastic Conditions

Extramammary Paget Disease

Kaposi Sarcoma

Myointimoma

Metastatic Tumors

Metastatic Tumors, Penis

Immunohistochemical Profiles for Tumors Involving Penis

Immunohistochemistry, Penis

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of genitourinary pathology, it incorporates the most recent clinical, pathologic, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Genitourinary is a one-stop reference for accurate, complete surgical pathology reports, ideal as a day-to-day reference or as a reliable training resource.

• Covers nearly 200 diagnoses of the kidney, prostate, bladder, testis, paratestis, and penis, including details on the rapid changes and continuous advances in the diagnosis of genitourinary cancers
• Includes new AFIP and WHO classifications/nomenclatures of tumors of the bladder, kidney, prostate, testis, and paratestis, as well as updated general concepts
• Contains the newest staging information released in the most recent AJCC Cancer Staging Manual, with a focus on practical issues pertaining to pathologic staging in resection specimens
• Provides expert guidance on differential diagnostic mimics in the text, as well as in the image galleries (unique to this book)
• Covers new and clinically relevant immunohistochemical (IHC) markers
• Provides relevant details and updates from the multiomic (or whole genome) approach as relevant to pathology practice
• Discusses the latest changes in precision medicine and continuous advances in oncology research, including the discovery of new urologic cancer biomarkers
• Features thousands of extensively annotated images, including gross pathology photographs, histopathology photomicrographs with a wide range of stains, and full-color illustrations
• Features a templated, highly formatted design; concise, bulleted text; diagnostic pearls, key facts in each chapter; and an extensive index for easy reference
• Includes the enhanced eBook version, which allows you to access all text, figures, and references on a variety of devices

Author Information

By Mahul B. Amin, MD, Clinical Professor, Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center Memphis, Tennessee, Adjunct Professor, Department of Urology, University of Southern California, Keck School of Medicine, Los Angeles, California and Satish K. Tickoo, MD, Attending Pathologist, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York