Management of Bleeding Patients

I: DIAGNOSIS OF BLEEDING BY LAB TESTING
1. Hemostasis Basics: Figures and Facts
2. Screening Coagulation Assays, FXIII and D-dimer
3. Platelets
4. Von Willebrand Disease Laboratory Workup
5. Hyperfibrinolysis
6. Whole Blood Assay: Thromboelastometry - Basics
7. Whole Blood Assay: Thromboelastometry - Bleeding Management Algorithms

II: BLEEDING ASSOCIATED WITH DISEASE CONDITION
8. Known Bleeding Disorders for Surgery
9. Hemophilia A, Hemophilia B, Congenital von Willebrand Disease, and Acquired von Willebrand Syndrome
10. Bleeding Associated with Coagulation Factor Inhibitors
11. Bleeding Due to Rare Coagulation Factor Deficiencies
12. Pregnancy-Associated Bleeding
13. Bleeding Associated with Thrombocytopenia
14. Bleeding in Acute and Chronic Liver Disease
15. Bleeding and Hyperfibrinolysis
16. Bleeding of Unknown Etiology
17. Bleeding Associated with Disseminated Intravascular Coagulation
18. Bleeding and Vitamin K Deficiency
19. Bleeding in Uremia
20. Bleeding Associated with Connective Tissue Disorders
21. Bleeding Associated with Trauma
22. Massive Transfusion Protocol
23. Lupus Anticoagulant Hypoprothrombinemia Syndrome (LAHPS)

III: BLEEDING FROM SPECIFIC ORGANS
24. Intracerebral Hemorrhage: An Overview of Etiology, Pathophysiology, Clinical Presentation, and Advanced Treatment Strategies
25. Epistaxis
26. Bleeding Disorders Related to Lung Disease
27. Heavy Menstrual Bleeding
28. Gross Hematuria
29. Upper Gastrointestinal Bleeding

IV: BLEEDING ASSOCIATED WITH MEDICATION
30. Antiplatelet and Anticoagulant Agents
31. Thrombolytic Therapy: tPA-Induced Bleeding

V: BLEEDING ASSOCIATED WITH PROCEDURE
32. Bleeding Associated with ECMO
33. Management of Bleeding Associated with Durable Mechanical Circulatory Support
34. Bleeding Related to Cardiac Surgery
35. Bleeding Related to Liver Transplant
36. Percutaneous Image-Guided Interventions Including Solid Organ Biopsies
37. Dental Extractions in Patients with Congenital and Acquired Bleeding Disorders

VI: SPECIFIC ISSUES IN NEONATES AND PEDIATRICS
38. Neonatal Thrombocytopenia
39. Bleeding in the Neonate

VII: EVALUATION OF BLEEDING RISK PRIOR TO INVASIVE PROCEDURES
40. Evaluation of Bleeding Risk Prior to Pediatric Invasive Procedures
41. Evaluation of Bleeding Risk Prior to Invasive Procedures

VIII: HEMOSTATIC AGENTS AND BLOOD COMPONENTS USED TO STOP BLEEDING
42. Hemostatic Agents and Blood Components Used to Stop Bleeding
43. Blood Components

This latest edition provides a comprehensive, state-of-the-art overview of the major issues specific to managing bleeding patients. Like the previous edition, the sections of this new edition have been structured to review the overall scope of issues, among them bleeding associated with disease condition, bleeding from specific organs, bleeding associated with medication, and bleeding associated with procedures. In addition to thoroughly revised and updated chapters from the previous edition, the latest edition features new chapters on such topics as the basics of hemostasis, bleeding due to rare coagulation factor deficiencies, bleeding associated with connective tissue disorders, massive transfusion protocol, bleeding associated with ventricular assist device, and evaluation of bleeding risk prior to invasive procedures. The volume also includes brief etiology and a practical reference guide regarding type of blood components, medication, dose, and duration.

Written by authors from a variety of integrated disciplines, Management of Bleeding Patients, Second Edition is a valuable resource for clinicians working in the area of bleeding management.

Jun Teruya, MD, DSc, FCAP Professor of Pathology & Immunology and Vice Chairman for Education Professor of Pediatrics Professor of Medicine Baylor College of Medicine Chief, Division of Transfusion Medicine & CoagulationTexas Children's Hospital Houston, TX USA