Textbook of Neural Repair and Rehabilitation, Vol. 1: Neural Repair and Plasticity

Description

In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

· Brings together the latest research in this rapidly developing field
· Written and edited by world-renowned experts in the field
· The first edition was a 'field-defining text'

Table of contents

Part I. Neural Plasticity – Cellular and Molecular Mechanisms of Neural Plasticity:
1. Degenerative changes and reactive growth responses of neurons following denervation and axotomy: historical concepts and their modern embodiments
2. Learning and memory: basic principles and model systems
3. Short-term plasticity: facilitation, augmentation, potentiation and depression
4. Long-term potentiation and long-term depression
5. Cellular and molecular mechanisms of associative and nonassociative learning

Part II. Functional Plasticity in the Central Nervous System:
6. Plasticity of mature and developing somatosensory systems
7. Activity-dependent plasticity in the intact spinal cord
8. Plasticity of cerebral motor functions: implications for repair and rehabilitation
9. Plasticity in visual connections: retinal ganglion cell axonal development and regeneration
10. Plasticity in auditory functions
11. Cross-modal plasticity in the visual system

Part III. Plasticity after Injury to the Central Nervous System:
12. The role of extracellular matrix in plasticity in the spinal cord
13. Spinal plasticity underlying the recovery of locomotion after injury
14. Cellular mechanisms of plasticity after brain lesions
15. Pathophysiology and plasticity in cerebral palsy
16. Noninvasive brain stimulation in cognitive rehabilitation: guiding plasticity after injury to the central nervous system
17. From bench to bedside: influence of theories of plasticity on human neurorehabilitation

Part IV. Neural Repair – Basic Cellular and Molecular Processes:
18. Neuronal death and rescue: neurotrophic factors and anti-apoptotic mechanisms
19. Axon degeneration and rescue
20. Adult neurogenesis and neural precursors, progenitors, and stem cells in the adult central nervous system
21. Axon guidance during development and regeneration
22. Synaptogenesis

Part V. Determinants of Regeneration in the Injured Nervous System:
23. Non-mammalian models of nerve regeneration
24. Myelin-associated axon growth inhibitors
25. Inhibitors of axonal regeneration
26. Glial development and their role in axon regeneration
27. Effects of the glial scar and extracellular matrix molecules on axon regeneration
28. The role of the inflammatory response in central nervous system injury and regeneration
29. Neurotrophin repair of spinal cord damage
30. Intraneuronal determinants of regeneration

Part VI. Promotion of Regeneration in the Injured Nervous System:
31. Cellular replacement in spinal cord injury
32. Dysfunction and recovery in demyelinated and dysmyelinated axons
33. Role of Schwann cells in peripheral nerve regeneration
34. Transplantation of Schwann cells and olfactory ensheathing cells as a therapeutic strategy in spinal cord injury
35. Trophic factor delivery by gene therapy
36. Assessment of sensorimotor function after experimental spinal cord injury and repair

Part VII. Translational Research: Application to Human Neural Injury:
37. Biomimetic design of neural prostheses
38. Brain responses to neural prostheses
39. Brain-computer interfaces
40. Intracranial brain-computer interfaces for communication and control
41. Stem cell therapies for brain disorders
42. Understanding motor recovery and compensation in neurorehabilitation

Index.