Microbiota-Gut-Brain Axis and CNS Disorders. Recent Progress And Perspectives

1. Introduction: An overview of Microbiota-Gut- Brain Axis

2. Role of Microbiota-Gut- Brain Axis in Alzheimer disease and possible interventions

3. Role of Microbiota Gut- Brain axis in Parkinson’s disease

4. Role of Microbiota-Gut- Brain Axis in Huntington’s disease and possible interventions

5. Role of Microbiota-Gut- Brain Axis in depression and anxiety

6. Role of microbiome- Gut Brain axis in autism spectrum disorder (ASD)

7. Role of Microbiota- Gut brain axis in autoimmunity and Multiple Sclerosis

8. Role of Microbiome Gut- Brain axis in stress

9. Role of Microbiota- Gut Brain Axis in epilepsy and possible interventions

10. Role of Microbiota- Gut Brain Axis in migraine and possible interventions

11. Role of Microbiota- Gut Brain Axis in stroke and possible interventions

12. Role of Microbiota- Gut Brain Axis in brain infections and possible interventions

13. Role of Microbiome Gut- Brain axis in brain disorders

14. Role of GUT microbiota in neuropsychiatric and neurological disorders

15. Role of Microbiota- Gut Brain Axis in Obesity on Cognitive Functions and Mood

16. Role of Microbiota- Gut Brain Axis on Neurotransmitters modulation

17. Role of gut virome and mycobiome in neurological disorders

18. Role of nutraceuticals in neurological diseases

19. Future prospective of Microbiome- Gut brain axis for treatment of CNS disorders

Microbiota-Gut-Brain Axis and CNS Disorders: Recent Progress and Perspectives on Human Disease summarizes the main findings on gut-brain axis in different types of CNS disorders, providing a complete overview of the field. The content helps unravel the complex interactions of the microbiota-gut-brain-axis in CNS disorders to pave a better understanding of microbiota-mediated pathogenesis, avenues for noninvasive prognosis, and therapeutic possibilities leveraging microbiota-gut-brain-axis modulations. Coverage includes the role of the microbiota-gut-brain axis and gut virome on human diseases including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Depression and Anxiety, Autism Spectrum Disorder, Multiple Sclerosis, Stroke, and others.

This book will satisfy the urgent need for a broader view of the current associations between gut microbiota alterations and development of CNS disorders, including the use of novel therapeutic approaches for restoring the correct intestinal bacteria content. It is the perfect reference for translational and clinical gut and microbiome researchers tackling the challenges of delivering genes and drugs in a more targeted and efficient manner for the treatment of CNS disorders.

• Discusses the development of both health and disease in interdisciplinary research involving gut microbiology
• Provides an understanding the role of Microbiome-Gut-Brain axis in neurodegenerative and neurodevelopmental diseases, including central nervous system (CNS) malignancies
• Delivers a compilation of current clinical studies to further investigate the role of diet in varying neurological disorders

Dr. Neeraj Mishra is a Professor and Head of the Department of Pharmaceutics at Amity Institute of Pharmacy, India, a position he has held since July 2019. With nearly two decades of teaching and research experience, Dr. Mishra has authored over 100 publications on novel drug delivery systems, focusing on nanocarriers and microparticles for treating breast and colon cancer, as well as neurodegenerative disorders. He has written several books and book chapters, and holds three international and two Indian patents. Dr. Mishra has received numerous accolades, including the "Distinguished Professor Award" (2019, 2021) and the "Outstanding Scientist Award" (2020). He has served as a guest editor for Bentham Sciences and is recognized in Stanford University's World Scientists Rankings for 2022 and 2024.

Dr. Anoop Kumar is an Assistant Professor in the Department of Pharmacology at Delhi Pharmaceutical Sciences & Research University (DPSRU), India. With a distinguished career, he has previously served as an Assistant Professor and Head at the National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, and as Head and Associate Professor at ISF College of Pharmacy, Moga, Punjab. Dr. Kumar has also held research positions at Sun Pharmaceutical Industries Limited and Translational Health Science Institute (THSTI). He earned his Ph.D. from Birla Institute of Technology, Mesra, Ranchi, as a DST INSPIRE Fellow. He is an Associate Editor for Health Sciences Review and Acta Neurologica Scandinavica. His research focuses on drug repurposing, clinical trial meta-analysis, pharmacoeconomics, and pharmacovigilance.