The potential for drugs to induce a range of cardiac adverse events is a critical issue facing the pharmaceutical industry; in the last 20 years, drug-induced QT prolongation and cardiac arrhythmias has represented an important cause of drug withdrawal. With FDA guidelines recommending stringent testing of new pharmaceuticals on the heart, the importance of cardiac electrophysiology is affecting an increasing number of professionals in a range of industries. This book will equip readers with a clear and solid foundation in the fundamentals of electrophysiology and pharmacology of the heart, explore clinical arrhythmia disorders and treatments, and relate this to the research and development of new medicines.
Representing an integrative bench to bedside approach to understanding this critical drug safety phenomenon, this book begins with a comprehensive review of the mechanisms responsible for drug-induced arrhythmia, followed by an in-depth discussion of the current preclinical and clinical recording techniques. Additionally, a complete assessment of current methods to stratify cardiac risk in drug development is included. Most importantly, the book develops and outlines novel strategies and key frameworks that could increase the safety, and drive down the risk, of novel biopharmaceutical products.
Readership: Drug safety professionals; physicians; pharmacologists; executives (such as venture capitalists or management consultants needing to gain a solid, but concise grasp of this subject to make more informed drug development, life cycle management and product planning decisions); basic scientists (at a university or pharmaceutical company); medical, pharmacology and physiology students.
- Physiology of the Heart
- Electrophysiology of the Heart
- Studying Cardiac Electrophysiology in the Laboratory and Clinic
- Electrical Disorders of the Heart: From Cell to Bedside
- The Impact of Cardiac Electrophysiology on Drug Development
- Case Studies of Drug-Induced Cardiac Toxicity
- The Future of Cardiac Drug Safety: Strategies to Reduce Risk and Ensure Continued Safety