Lynch Syndrome. Molecular Mechanism and Current Clinical Practice

1 Molecular mechanism of Lynch syndrome
2 Clinical features of Lynch syndrome
3 Pathology of Lynch syndrome-associated tumors
4 Immunohistochemistry for mismatch repair proteins
5 Genetic analysis for Lynch syndrome
6 Lynch syndrome-associated gynecological malignancies
7 Lynch syndrome-associated urological malignancies
8 Screening for Lynch syndrome
9 Surveillance Colonoscopy for Lynch Syndrome Patients
10 Surgical approach for colorectal cancer in patients with Lynch syndrome
11 Immunotherapy for Lynch syndrome patients
12 Chemoprevention for Lynch syndrome-associated malignancies
13 International collaboration for Lynch syndrome

This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition.

Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease's manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome.

Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.

Naohiro Tomita, Professor Emeritus,
Division of Lower GI Surgery,
Department of Surgery,
Hyogo College of Medicine
Nishinomiya, Hyogo, Japan
Specially Appointed Adviser,
Cancer Treatment Center,
Toyonaka Municipal Hospital
Toyonaka, Osaka, Japan
ntomita@hyo-med.ac.jp