Part-1: Introduction1.OverviewPart-2: Disease Modeling2. iPSCs for disease modeling3.Reprogramming cancer cells4. Recapitulating hematopoiesis in the lab5. Modeling cardiomyopathies with iPSCsPart-3: Molecular Technologies6. Controling cell state with intracellular biomarkers7. Genome editing of stem cellsPart-4: iPS Applications8. iPSC-based cell therapy for eye diseases9. 3D models for organ development10. Drug discovery using iPSCs11. Direct differentiation of neural cells
This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.
Haruhisa Inoue, CiRA, Kyoto University, Japan; RIKEN BRC, Japan; RIKEN AIP, JAPAN
Yukio Nakamura, RIKEN BioResource Center, Japan