About this book
- This is the first comprehensive volume regarding the multiple medication use in psychiatry
- Preclinical and clinical investigation of the multiple medication use in psychiatry
- Evidence-based monitoring important research developments in this field
Despite the large number of psychotropic medications currently available, effective management of mental disorders continues to be a challenging task. Although monotherapy may be desirable, most patients require combinations of two or more psychotropic drugs. Polypharmacy aims to address different aspects of treatment resistance, especially insufficient response of positive and negative symptoms, cognitive disturbances, affective comorbidity, obsessive-compulsive syndromes and side-effects of antipsychotic agents. At the same time, evidence based guidelines in support of polypharmacy, and augmentative strategies are scant.
This two-volume collection is the first comprehensive, clinically oriented, reference text on polypharmacy (co-administration of more than one medication) or the use of multiple preparations to treat psychotic, cognitive, mood and anxiety disorders. This collection is dividedinto four parts.
Volume I contains two parts including chapters that serve as an introduction and overview of conceptual issues. Key topics include: rational polypharmacy, receptor binding targets, drug interactions, preclinical and clinical investigations in this field, dosing regimens, multiple medication use in forensic psychiatry, a naturalistic trial, adjunctive strategies, and multiple medication use for the treatment of somatic symptom disorders.
Volume II contains two parts that focus on antipsychotic polypharmacy for schizophrenia, and clinical practice in the USA, Czech Republic, Ukraine, and Italy, polypharmacy and associated phenomena, clozapine combinations and the metabolic syndrome. The authors discuss combination therapy for bipolar disorder, major depressive disorder, obsessive-compulsive syndromes in schizophrenia, and potentially inappropriate medication use among elderly patients with dementia.
Finally, each volume includes Appendix contains ‘Annotated bibliography on polypharmacy’ and ‘List of Psychotropic Medications’.
Table of contents
About the Editor
Part I. Polypharmacy treatment strategies
- 1. Multiple medication use in psychiatry: How Rational Can It Be? Ahsan Khan and Sheldon Preskorn
- 2. Receptor binding targets for antipsychotic efficacy; Maureen M. Grainger, Rebecca Ahlbrand, Paul S. Horn, Neil M. Richtand
- 3. Drug interactions and polypharmacy; Jessica L. Gören, and Ashley Tewksbury
- 4. Preclinical and clinical investigation of antipsychotic polypharmacy: What is the evidence?Dimitrios Kontis, Eirini Theochari
- 5. Should high dose or very long-term antipsychotic monotherapy be considered before antipsychotic polypharmacy? Stephen M. Stahl and Debbi A. Morrissette
- 6. Multiple Medication Use of Neuropsychiatry in Forensic Psychiatry: Findings from theCentral State Forensic Psychiatric Hospital of Saxony-Anhalt; Joachim G. Witzel
Part II. Augmentation strategies
- 7. Antipsychotic treatment within a naturalistic trial - how are we treating schizophrenia patients in the "real-world"? Rebecca Schennach, Michael Obermeier, Florian Seemüller, Daniela Krause, Richard Musil, Ilja Spellmann, Hans-Jürgen Möller, Michael Riedel
- 8. A multi-target drug treatment in schizophrenia using adjunctive agents
with non-D2mechanisms of action; Michael S Ritsner
9. Antidepressants in schizophrenia – a place for them? Viacheslav Terevnikov and Grigori Joffe
- 10. Stressful life events and anticonvulsant medication in psychiatric patients;
11. Multiple medication use in somatic symptom disorders: from augmentation to diminution strategies; Adrian P. Mundt
Appendix; Rena Kurs
Annotated bibliography on polypharmacy
List of Psychotropic Medications
Contents to Volume II
Contributors to Volume II