Transfusion Guide for Clinicians

Table of Contents

1. Guidelines for Clinical Transfusion Procedures
• Clinical Decisions on Transfusion
• Assessing the Need for
• Transfusion
• Checklist for Clinicians Prescribing Blood
• Requisition for Blood/Blood Components
• Informing the
• Patien
• Ordering Blood
• Blood Samples
• Donor
• Protocol for Apheresis Donor
• Cross-Match of Blood
• Issue of Blood Units
• Collecting Blood/Products Prior to Transfusion
• Components
• Dose/Outcome of Blood/Blood Components
• Storing Blood Products Prior to Transfusion
• Administering Blood Products
• Time Limits for Infusion
• Disposable Equipment for Transfusion
• Blood Warming
• Pressure Devices for Rapid Infusion
• Recording the Transfusion
• Monitoring the Transfused Patiens
• Acute Transfusion Reactions
• Protocol for Adverse Reaction of Blood Transfusion
2. Blood Components and its Uses
• Packed Red Blood Cells
• Leukoreduced Red Cells
• Platelets
• Fresh Frozen Plasma
• Cryoprecipitate
• Granulocytes
• Irradiated Red Cells
• Cryopreserved Red Cells
3. Apheresis
• Applications
• Separai on Techniques
• Donor Aspects
• Apheresis Components
• Therapeutic Apheresis
• Therapeutic Plasmapheresis (Plasma Exchange)
• Peripheral Blood Stem Cells
4. Transfusion Practices in Clinical Medicine
• Massive Transfusion
• Disseminated Intravascular Coagulai on
• Muli -Transfused Patiens
• Sickle Cell Anemia
• Thalassemia
• Hemophilia
• von Willebrand’s Disease
• Disorders of Vitamin K-Dependent Coagulai on Factors
• Malaria
• Autoimmune Hemolyi c Anemia
• Anemia
• Severe (Decompensated) Anemia
• Glucose--Phosphate Dehydrogenase Defi ciency
• Bone Marrow Failure
• Gastrointesi nal Bleeding
5. Transfusion Practice in Obstetrics
• Blood Loss during Delivery
• Transfusion Guidelines for Chronic Anemia in Pregnancy
• Major Obstetric Hemorrhage
• Disseminated Intravascular Coagulation
• Hemolytic Disease of The Newborn
6. Neonatal and Pediatric Transfusion Practice
• Neonatal Transfusion
• Hemolyi c Disease of Newborn
• RhD Hemolytic Disease of Newborn Exchange Transfusion
• ABO Hemolyi c Disease of the Newborn
• Indirect Hyperbilirubinemia
• Pediatric Anemia
• Bleeding and Cloting Disorders in Pediatrics
• Acquired Bleeding and Cloting Disorders
• Thrombocytopenia
• Red Cell Transfusion
• Neonatal Alloimmune
• Thrombocytopenia
• Fresh Frozen Plasma in Pediatrics
7. Transfusion Practice in Surgery and Hemorrhage
• Red Blood Cell Transfusion in Anemia
• Anemia and Surgery
• Recombinant Aci vated Factor VII
• Surgery and Coagulation Disorders
• Ani coagulants: Warfarin, Heparin
• Management of a Bleeding Patien who has Received Fibrinolytics or Platelet Inhibitors
• Transfusion in Elective Surgery
8. Approach to a Patien of Trauma and Burns
• Phase I: Assessment and Resuscitation
• Phase II: Reassessment
• Phase III: Defi nii ve Management
• Pediatric Patiens
• Approach to a Patient of Burns
9. Transfusion in Cardio-Pulmonary Bypass Surgery
• Thromboelastography
10. . Transfusion in Transplantation
• Transfusion in Bone Marrow Transplantation
• Transfusion in Solid Organ Transplantation
11. Transfusion Transmited Infections
• Window Period
• HBV
• HCV
• HIV
• Syphilis
• Malaria
• Viral Inactivation
• Pathogen Inactivation
• Role of the Clinicians
• Prevalence of TTIs
• How Safe is Transfusion?
• Nucleic Acid Testing
12. Transfusion Reactions—Protocol
• Classification of TRs
• Acute/Immediate Reactions
• Delayed Transfusion Reactions
• Management and Investigations
• Lab Studies
• Transfusion Transmited Infections—Delayed Complications of Transfusion
• Errors in Transfusion Process
• Preveni on of TRs
• SHOT UK Report 1996-2009
13. Autologous Transfusion
• Types of Autologous Transfusion
14. Fresh Blood
15. Blood Group Choice
16. Umbilical Cord Blood
17. Hospital Transfusion Committee
18. Plasma Derivatives and Plasma Subtitutes (BL Bhardwaj, Aastha Miranpuri)
• Plasma Protein Solutions
• Factor VIII Concentrate
• Factor IX Containing Plasma Derivatives
• Immunoglobulin Preparations
• Plasma Subtitutes
19. Alternatives to Transfusion (BL Bhardwaj, Aastha Miranpuri)
• Pharmacological Agents
• Recombinant Hematopoietic Growth Factors
• Red Cell Subtitutes
• Platelet-Derived Products
20. Recent Advances in Transfusion
• Proteomics
• Gene Therapy
• Pathogen Inactivation System
• Adoptive Immunotherapy
• Recent Advances in Apheresis
21. Frequently Asked Questions about Transfusion (BL Bhardwaj, Aastha Miranpuri)
22. Abbreviations
23. Glossary
24. Appendices
1. Blood Requisition Form
2. Informing Patiens
3. Consent Form for the Transfusion of Blood/Blood Components
4. Donor Form
5. Transfusion Reaction Form
6. Transfusion Reaction Protocol for Clinicians
7. Good Transfusion Practices
8. Normal Hematological Values in Adults
9. Normal Hematological Values in Children
10. Criteria for Anemia
11. Directed Donation
12. Patiens who do not Accept Transfusions
25. Suggested Reading
26. Index