ABOUT THIS BOOK
- Provides an up to date review on bacterial chromatin
- Covers the molecular and cellular level across disciplinary boundaries
- Addresses cross-kingdom differences and similarities
- Outstanding quality of the authors – the chapters are written by the world's leading experts in the field
The relative simplicity of the bacterial cell, short generation times and
well defined and inexpensive culturing conditions have significantly contributed
to our understanding of many complex biological systems. Yet the workings of
the bacterial genome, seemingly impossibly compressed within a tiny nucleoid,
have remained elusive. How is it that bacteria are able to package their genetic
information within the confined space of the nucleoid while at the same time
making it accessible for gene expression and DNA replication?
This book, featuring the latest research by leading experts, describes the advanced methods being applied to the problem and shows how their work is contributing to our growing understanding of the ways that bacterial DNA storage, replication, recombination and gene expression are managed and coordinated. With due consideration paid to archaea and eukaryotes, the authors show how evolution in bacteria has provided solutions to these problems that range from the very sophisticated to the surprisingly simple.
This comprehensive overview of bacterial chromatin clearly defines the fundamental concepts and goes on to show how cells inherit both chromosomal and extra-chromosomal genetic information at cell division. Several chapters are devoted to the central role played by nucleoid-associated proteins, with specific material on imaging the nucleoids, the physics of their structure and segregation, and the transcriptional regulation conducted by nucleoid-associated proteins. No other book currently available provides such a complete picture of these essential cellular processes.
Written for » Research
Related subjects » Biochemistry & Biophysics - Biomedical Sciences - Biophysics & Biological Physics - Microbiology
TABLE OF CONTENTS
Claudio O. Gualerzi
Structure and organization of the bacterial chromosome
Remus T. Dame
"Ultrastructure and organization of bacterial chromosomes"
1. William Margolin "Imaging the bacterial nucleoid"
2. Peter L. Graumann "The chromosome segregation machinery in bacteria"
3. Finbarr Hayes and Daniela Barillà "Extrachromosomal components of the nucleoid: recent developments in deciphering the molecular basis of plasmid segregation"
4. Conrad Woldringh "Nucleoid structure and segregation"
5. Suckjoon Jun "Physics of nucleoid structure and chromosome segregation"
6. N. Patrick Higgins, Betty M. Booker and Dipankar Manna "Molecular structure and dynamics of bacterial nucleoids"
7. Ümit Pul and Rolf Wagner "Nucleoid-associated proteins: structural properties"
8. Hanne Ingmer "Dps and bacterial chromatin"
Chromatin organization in archaea and eukaryotes
9. Stephen D. Bell & Malcolm F. White "Archaeal chromatin organization"
10. Andrew Travers and Georgi Muskhelishvili "The topology and organization of eukaryotic chromatin"
Regulation by nucleoid-associated proteins
Charles J. Dorman "Bacterial chromatin and gene regulation"
11. William W. Navarre "H-NS as a defense system"
12. Georgi Muskhelishvili and Andrew Travers "FIS and nucleoid dynamics upon exit from lag phase"
13. Stacey N. Peterson and Norbert O. Reich "LRP: a nucleoid-associated protein with gene regulatory function"
14. Amalia Muñoz, Marc Valls and Víctor de Lorenzo "Extreme DNA bending: molecular basis of the regulatory breadth of IHF"
15. Dale E. A. Lewis, Sang Jun Lee and Sankar Adhya "Role of HU in regulation of gal promoters"
16. Douglas F. Browning, David C. Grainger, Meng Xu and Stephen J.W. Busby "Transcriptional regulation by nucleoid-associated proteins at complex promoters in Escherichia coli".