Cover copy: Wolf, Norman (ed.), The Comparative Biology of Aging
The processes of aging and death remain one of the most fascinating, and mysterious, areas of biological research. Huge anomalies between species raise questions the answers to which could have fundamental implications for the field of medical science. As scientists unlock the secrets of the exceptionally long-lived little brown bat (up to 34 years), or the common Budgerigar, for example, which despite having a metabolic rate 1.5 times that of a laboratory mouse, can live for up to 20 years, it has become more important than ever to be able to make a comparative analysis of the various species used in research.
Dealing with every one of the mammalian species that are employed in laboratory research, this is the first book on the subject of aging that provides detailed comparative data for age-related changes in its subjects. It does so at the level of the whole animal, its organs, organelles and molecules. The comparative data, supplied in 15 chapters by leading experts, provides information on fields as disparate as telomere function and loss, the importance of the Sirtuins and Tor, the influence of hormones on lifespans, the relationship between body size and lifespan, the effects of restricted calorific intake, age-related changes in cell replication, and DNA damage and repair. Chapters are devoted to cardiac aging, comparative skeletal muscle aging, the aging of the nervous and immune systems, the comparative biology of lyosomal function and how it is affected by age, and many other key areas of research.
This much-needed text will provide scientists working in a wide spectrum of fields with key data to aid them in their studies.
Written for: Research institutes, universities, scientists
in the field of aging, gerontologists
Table of contents
1. Introduction and end of life pathologies
Norman Wolf and Steven Austad
2. Animal size, metabolic rate, and survival, among and within species
3. Hormonal Influences on Aging and Lifespan
Adam Spong and Andrzej Bartke
4. Exploring mechanisms of aging retardation by caloric restriction: studies
in model organisms and mammals.
Rozalyn Anderson, Ricki Colman & Richard Weindruch
5. Cell Replication Rates In Vivo and In Vitro and Wound Healing as Affected
by Animal Age, Diet, and Species.
6. The Comparative Biology of Sirtuin Function in Longevity
Daniel L. Smith, Jr., and Jeffrey S. Smith
7. The Role of TOR signaling in Aging.
Matt Kaeberlein and Lara S. Shamieh
8. Mitochondria, Oxidative Damage and Longevity: What Can Comparative Biology
Yun Shi, Rochelle Buffenstein and Holly Van Remmen
9. Comparative genomics of aging.
Jan Vijg, Ana Maria Garcia, Brent Calder and Martijn Dollé
10. Changes in lysosomes and their autophagic function in aging. The comparative
biology of lysosomal function.
Samantha J. Orenstein and Ana Maria Cuervo
11. Telomeres and telomerase. Inter-species comparisons of genetic, mechanistic
and functional aging changes.
N.M.V. Gomes, J.W. Shay, W.E. Wright,
12. Cardiac Aging.
Dao-Fu Dai, Robert J. Wessells, Rolf Bodmer, Peter S. Rabinovitch
13. Comparative Skeletal Muscle Aging.
David J. Marcinek, Jonathan Wanagat, Jason J. Villarin
14. Aging of the Nervous System.
Catherine A. Wolkow, Sige Zou and Mark P. Mattson
15. Aging of the Immune System across Different Species.
Janko Nikolich-Zugich and Luka Cicin-Sain