"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome.
The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases.
The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis.
This book will be a valuable resource for researchers investigating the role of apoptosome-dependent cell death in cancer and other diseases, for researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance and for physicians using chemotherapeutic agents. Additionally, this book will be an important educational source for PhD students and MD students specializing in molecular and cell biology, and to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of programmed cell death.
Written for: Molecular and cell biologists, clinical researchers, pharmacologists, Ph.D., MD students
Keywords: ApoptosomeTable of contents
Introduction; F.Cecconi, M. D’Amelio
1. Physiological and Pathological Role of Apoptosis; V. Cavallucci, M. D’Amelio
2. Apoptosome structure and regulation; E. Ferraro, C. Fuoco, F. Strapazzon, F. Cecconi
3. Chemical regulation of the apoptosome: new alternative treatments for cancer; K. Cain
4. Molecules that bind a central protein component of the apoptosome, Apaf-1,and modulate its activity; L. Mondragón, M. Orzáez, A. Gortat, M. Sancho, A. Messeguer, M.J. Vicent and E. Pérez-Payá
5. Regulation of cell death and survival by RNA interference – The roles of miRNA and siRNA; P. Lingor
6. Beneficial role of taurine against myocardial apoptosis during ischemic injury; T. Ito, S .W. Schaffer, J. Azuma
7. BAG3 protein: role in some neoplastic cell types and identification as a candidate target for therapy; M. Pascale, A. Rosati, M. Festa, A. Basile, M. d’Avenia, A. Falco, G. Torino and M.C. Turco
8. Targeting Survivin in cancer therapy: Pre-clinical studies; M. Pennati, M. Folini and N. Zaffaroni
9. Hsp70 and Hsp27: Emerging Targets in Cancer Therapy; A.L. Rérole, A.L. Joly, D. Thuringer and C. Garrido
10. Role of the RNA-binding protein HuR in Apoptosis and Apoptosome Function; Y. Kuwano, I. Gallouzi, and M. Gorospe
11. Acetylcholinesterase as a Pharmacological Target in Cancer Research; S.E. Park, Y.H. Yoo
12. Putative role of HCA66, a new Apaf-1 interacting protein, in the physiopathology of NF1 microdeletion syndrome patients; P. Rigou, A. Faye and J.L. Poyet
13. Cristae remodeling and mitochondrial fragmentation: a checkpoint for cytochrome c release and apoptosis?; L. Scorrano
14. Apoptosome pharmacological manipulation: from current developments in the laboratory to clinical implications; M. D’Amelio and F.Cecconi
15. The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury; R. Kingston
16. Targeting survivin in cancer therapy: Clinical considerations; T. Tsuruma, H. Kameshima, Y. Iwayama, T. Torigoe, Y. Hirohashi, N. Sato, K. Hirata