The Dna Damage Response. Implications on Cancer Formation and Treatment

About this book

• Offers an up-to-date and comprehensive review of the latest advances in DNA damage sensing, signaling and repair Describes current bottlenecks and future directions
• Discusses the relationship between DNA damage repair and cancer
• Written by active investigators who have made important contributions in their respective areas

The book The DNA Damage Response: Implications on Cancer Formation and Treatment brings together a great collection of review articles. The articles have been written by a group of experts who have a deep knowledge of the recent advances in the fields of DNA damage signalling and repair and their implications in carcinogenesis.

The book is divided into chapters that deal with the elaborate surveillance system and repair mechanisms used by cells to suppress mutagenic lesions to avoid cancer. It provides snapshots of:

* current understanding of DNA damage signalling,
* cell cycle checkpoints,
* some of the major DNA repair pathways,
* functional links between DNA damage,
* genomic instability and cancer,
* implications of DNA damage for the development of new treatment modalities for cancer.

Written for » Research
Keywords » DNA Damage
Related subjects » Cancer Research - Human Genetics - Immunology - Neuroscience - Oncology & Hematology

Table of contents

1. DNA damage sensing and signaling; Daniel Durocher
2. Signaling at stalled replication forks; David Cortez, Daniel A. Mordes
3. Replication Stress and Cancer Development; Thanos D. Halazonetis
4. Cellular responses to oxidative stress; Ari Barzilai, Inbal Dar
5. Cell Cycle Regulation and DNA damage response; Randal S. Tibbetts et al.
6. Chromatin changes involved in DNA damage response; Kum Kum Khanna et al.
7. Telomere Metabolism and DNA Damage Response; Tej K. Pandita
8. DNA double strand break repair: mechanisms and therapeutic potential; Susan P. Lees-Miller et al.
9. DNA Base Excision Repair: A Recipe for Survival; Sankar Mitra, Rabindra Roy
10. DNA damage tolerance and translesion synthesis; Alan R. Lehmann
11. Nucleotide excision repair; Leon H.F. Mullenders, Mischa G. Vrouwe
12. Single-strand Break Repair; Keith W. Caldecott
13. Mouse models of repair deficiency; Sachin Katyal, Peter J. McKinnon
14. Cancer biomarkers associated with damage response genes; Anne W. Kiltie et al.
15. Linking RecQ helicases to damage response and aging; Wen-Hsing Cheng et al.
16. Single stranded DNA binding proteins and genome maintenance; Derek J. Richard, Kum Kum Khanna
17. The Fanconi anemia-BRCA pathway and cancer; Toshiyasu Taniguchi
18. BRCA1 and BRCA2: roles in Cancer formation and treatment; Kienan Savage, D. Paul Harkin