This book provides detailed information on therapeutic radiopharmaceuticals
and discusses emerging technologies which have potential for broad clinical
implementation. Recent advances in molecular biology, radiopharmaceutical chemistry
and radioisotope production have stimulated a new era for the use of radiopharmaceuticals
for targeted radionuclide therapy (TRT). Emerging clinical trials include use
of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides
for cancer therapy. In addition, small molecules are used for the treatment
of chronic diseases such as metastatic bone pain palliation and radiation synovectomy
of inflammatory joints. In the interventional arena, therapy of primary and
metastatic liver cancer and arterial restenosis following angioplasty of both
the coronary and peripheral arteries are being explored. Reactor and accelerator
production of therapeutic radioisotopes is also integrated into these discussions.
The development and use of radiopharmaceutical targeting characteristics required
for treatment of specific disease processes and how these are implemented for
radiopharmaceutical design strategies are also described.
Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.
Chapter 1-Introduction-Radiopharmaceuticals Play an Important Role in both Diagnostic and Therapeutic Nuclear Medicine.- Chapter 2 - Therapeutic Radionuclides Decay with Particle Emission for Therapeutic Applications.- Chapter 3 - Alpha Radionuclide Therapy.- Chapter 4-Auger Electron-Based Radionuclide Therapy.- Chapter 5-Reactor-Produced Therapeutic Radionuclides.- Chapter 6-Accelerator-Produced Therapeutic Radionuclide.- Chapter 7-Radionuclide Generator Systems Represent Convenient Production Systems to Provide Therapeutic Radionuclides.- Chapter 8-Alpha-Emitting Radionuclide Production.- Chapter 9 - Radioimmunotherapy (RIT).- Chapter 10-Peptides for Receptor Radionuclide Therapy (PRRT).- Chapter 11-Therapeutic Radiopharmaceuticals for Treatment of Primary and Metastatic Hepatic Cancer.- Chapter 12-Therapeutic Radiopharmaceuticals for Bone Pain Palliation.- Chapter 13-Locoregional Radionuclide Therapy for Non-Melanoma Skin Cancer (NMSC).- Chapter 14-Radionuclide Synovectomy - Treatment of Inflammation of the Synovial Joints.- Chapter 15 - Inhibition of Arterial Restenosis following Balloon Angioplasty.- Chapter 16 - Moving Forward - Expected Opportunities for the Development of New Therapeutic Agents Based on Nano Technologies.- Chapter 17. Translation of Radiopharmaceuticals From Bench to Bedside - Regulatory and Manufacturing Issues.