Pain, a complex experience comprising of a physiological and a psychological reaction to a noxious stimulus .Most of the time the patients rush to reach a dentist is pain. Tooth pain could be of either odontogenic or non-odontogenic origin. The orofacial pain from dental origin was specifically called “odontogenic toothache.” However, some toothaches may non-dental origin. Toothache of non-dental origin is the pain referred to the dentition from distant site .This book covers the various types of non odontogenic pain and their important clinical aspects. The cross - speciality knowledge regarding non odontogenic pain would be of great aid for the physician while arriving a treatment plan.