Lens Epithelium and Posterior Capsular Opacification

About this Book

• Describes the pathobiology of posterior capsular opacification and the molecular mechanism of lens epithelial cells as closely interconnected factors Outlines surgical approaches to prevent posterior capsular opacification Each chapter is written by internationally respected authors who are leaders in their respective fields

Posterior capsular opacification (PCO) remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications that tend to occur during or soon after the procedure. Opacification of the posterior capsule appears to be linked to lens epithelial cells that are left behind in the eye during cataract removal. These cells proliferate, migrate across the posterior lens capsule and undergo changes that result in fibrous or pearl-type opacities in the capsule. This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation and the development of PCO. The first section of the text explains the molecular mechanism and biology of lens epithelial cells, which lead to incidents of PCO. In the second part, in addition to a description of the mechanism and pathological condition of PCO, surgical methods and devices for preventing PCO are discussed in detail. Lens Epithelium and Capsular Opacification will benefit not only young clinical residents and junior researchers, but also established faculty in the clinical or basic academic field.

Content Level » Professional/practitioner
Keywords » biomaterial - cataract surgery - growth factor - intraocular lens - lens epithelial cell - postoperative capsular opacification
Related subjects » Biomedical Sciences - Cell Biology - Molecular Medicine - Ophthalmology

Table of Contents

Preface by Editor and co-editors Shizuya Saika, Frank Lovicu, Lilliana Werner PART?:BASIC SCIENCE .- Chapter1. Lens epithelial morphogenesis. Michael Robinson .- Chapter 2. Biology of lens epithelial cells. Steve Bassnett .- Chapter 3. Lens capsule (synthesis and remodeling; MMPs). Judy West-Mays .- Chapter 4. Growth factor signaling in lens epithelial proliferation. Frank Lovicu, John McAvoy .- Chapter 5. Growth factor signaling in lens fiber differentiation. Robb de Iongh, Melinda Duncan .- Chapter 6. Lens-specific transcription factors: implications for congenital cataract. (Joachim Graw and Ales Cvekl) .- Chapter 7. Lens regeneration. (Panagiotis Tsonis) .- Chapter 8. Lens EMT: Fibrosis in the lens. Michael Wormstone .- Chapter 9. Lens EMT: Wound healing in lens epithelial cells. Shizuya Saika Part?: CLINICAL SCIENCE -PATHOLOGY- .- Chapter 10. Histology of PCO. Shizuya Saika .- Chapter 11. PCO rates in a large series of human eyes obtained postmortem. Liliana Werner Part?: CLINICAL OUTCOMES .- Chapter 12. Natural course of Elschnig pearl formation and disappearance. Oliver Findl .- Chapter 13. Effect of PCO on the visual function in eyes implanted with different IOLs. Ken Hayashi PART?: SURGICAL METHODS FOR PCO PREVENTION .- Chapter14. Effect of anterior capsule polishing on PCO. Rupert Menapace .- Chapter15. Sealed capsule irrigation and PCO prevention. Gerd Auffarth .- Chapter16. Laser photolysis system and PCO prevention. Nick Mamalis PART?: INTRAOCULAR LENSES/DEVICES AND PCO .- Chapter17. PCO prevention: IOL material versus IOL design. Liliana Werner .- Chapter18. Capsular biocompatibility of different IOLs in eyes with and without associated conditions. Michael Amon .- Chapter19. Capsular bending ring to prevent PCO. Okihiro Nishi .- Chapter20. PCO prevention with endocapsular equator rings. Tsutomu Hara .- Chapter21. PCO prevention with IOL maintaining an open or expanded capsular bag. Liliana Werner .- Chapter22. Prevention of PCO with the Bag-in-the-lens. Marie-José Tassignon .- Chapter23. Microincision IOLs and PCO. David Spalton PART?: SPECIAL CASES .- Chapter24. PCO and the pediatric eye. Abhay Vasavada

Authors & Editors

Shizuya Saika, MD, PhD. Professor and Chairman, Department of Ophthalmology Wakayama Medical University School of Medicine 811-1 Kimiidera, Wakayama, 641-0012, Japan TEL: 81-73-447-2300 (5412) FAX: 81-73-448-1991 shizuya@wakayama-med.ac.jp

Liliana Werner, MD, PhD Associate Professor Co-Director, Intermountain Ocular Research Center John A. Moran Eye Center University of Utah 65 Mario Capecchi Drive, Salt Lake City, UT 84132 USA TEL: +1 801 581 6586 FAX: +1 801 581 3357 E-mail: liliana.werner@hsc.utah.edu http://uuhsc.utah.edu/MoranEyeCenter/research/faculty/primary/mamalis_werner_lab.htm

Frank J. Lovicu, PhD Associate Professor, Lens Research Laboratory Anatomy & Histology, School of Medical Sciences Bosch Institute & Save Sight Institute The University of Sydney Rm S252, Anderson Stuart Building, F13 NSW 2006, Australia TEL: +61 2 9351 5170 FAX: +61 2 9351 2588 E-mail: frank.lovicu@sydney.edu.au