Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest
human pathogens within the Paramyxoviridae family. This volume deals with the
many facets of henipavirus biology, and covers our current understanding regarding
the ecology, molecular virology, and pathogenesis of henipavirus infections.
It is an international effort written by a multidisciplinary panel of experts
at the front lines of research into this lethal emerging group of paramyxoviruses.
The first section introduces the epidemiology and ecology of Nipah and Hendra
viruses in their respective endemic areas, including a first-hand account of
the discovery of Nipah virus during its initial outbreak in Malaysia; the next
section documents the molecular virology of henipaviruses, and the substantial
advances made towards understanding the unique features of henipavirus entry
and tropism; and this is followed by accounts of the clinical and pathologic
features of henipavirus infections in their human and naturally infected animal
hosts. The next sections on pathogenesis provide a comprehensive reference on
how henipaviruses counteract the innate immune system, and the relevant pathogenic
features in animal challenge models developed to test potential therapeutic
strategies. The final sections describe our current and future capabilities
for diagnosis and control, including an account of potentially effective immunization
strategies that are currently being tested.
This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.