Hepatitis C Virus: From Molecular Virology to Antiviral Therapy (Current Topics in Microbiology and Immunology, Vol. 369)

Description

· A comprehensive review
· Written by leading experts
· Richly illustrated

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Table of contents

• The Origin of Hepatitis C Virus
  Peter Simmonds

• Cell Culture Systems for Hepatitis C Virus
  Eike Steinmann and Thomas Pietschmann

• Animal Models for Hepatitis C
  Eva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, and Alexander Ploss

• Hepatitis C Virus Entry
  Mirjam B. Zeisel, Daniel J. Felmlee, and Thomas F. Baumert

• Hepatitis C Virus Proteins: From Structure to Function
  Darius Moradpour and François Penin

• Hepatitis C Virus RNA Translation
  Michael Niepmann

• Hepatitis C Virus RNA Replication
  Volker Lohmann

• Virion Assembly and Release
  Brett D. Lindenbach

• Innate Immune Responses to Hepatitis C Virus
  John W. Schoggins and Charles M. Rice

• Adaptive Immune Responses in Hepatitis C Virus Infection
  Christoph Neumann-Haefelin and Robert Thimme

• Liver Injury and Disease Pathogenesis in Chronic Hepatitis C
  Daisuke Yamane, David R. McGivern, Takahiro Masaki, and Stanley M. Lemon

• Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
  Leen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, and Raffaele De Francesco

• Treatment of Chronic Hepatitis C: Current and Future
  Jean-Michel Pawlotsky