About this book
Obesity is considered as top at risk condition in the world and it is mandatory
to identify the physiopathological causes involved in adipose tissue enlargement
and related metabolic and cardiovascular health disorders. Environmental, behavioural,
genetic, epigenetic and multiple biological factors interact to cause obesity.
In this context adipose tissue depots have been under focus in the last decades
and pivotal concepts have emerged from the studies of their complex biology.
While the white adipose tissue (WAT) is the main energy repository in the body
(mobilizing fatty acids according to body needs) thanks to white adipocyte properties,
WAT is also a multicellular organ communicating with other body organs (brain,
muscles, liver, pancreas, heart, vessels, etc…) via complex networks of
endocrine signals. The discovery of leptin in 1994 led to recognize WAT as a
master organ at the crossroad of a myriad of physiological interactions to control
food intake, energy balance, glucose and lipid metabolism, immunity and reproduction.
The phenotype, amount and biology of each WAT component are profoundly altered
in human obesity. Adipose plasticity also accounts for the extraordinary capacity
of adipose precursors to differentiate into functional cardiomyocytes, osteoblasts,
haematopoietic and neural cells, a convenient property for regenerative medicine.
Finally, while initially thought to exert a negligible role in humans, the discovery
of brown adipose tissue in adults stimulates a novel interest for this tissue
with high capacity to oxidize fatty acids
Content Level » Research
Keywords » adipose tissue dysfunction - anti-obesity therapy - brown adipose tissue - leptin - white adipose issue
Related subjects » Biomedical Sciences
Table of contents
Preface.- Pathological alteration of human adipose tissue in obesity.- Dynamics of human adipose tissue. regulatory mechanisms and consequences for fat cells and whole body.- Metabolism of fatty acids in adipocytes.- Hypoxia – role in adipocyte function and dysfunction.- Brown adipose tissue in humans – a new target for anti-obesity therapy.- Adipose tissue dysfunction: a multistep process.- Fat cell progenitors: origins and plasticity.- Transcriptional regulation of brown and white adipogenesis.- Transcriptional Control of Gene Expression in Different Adipose Tissue Depots.- Epigenetic approaches to adipose biology.- Metabolic and angiogenic consequences of the presence or absence of UCP1.- Metabolic responses to weight perturbation.- Understanding causal relationships in the metabolic syndrome – recent insights from extreme human phenotypes.- Subject index