Color Atlas of Herpetic Eye Disease. a Practical Guide to Clinical Management

About this book

• Offers practical advice for the recognition and management of each Herpetic Eye problem
• Based on nearly four decades of practical and scientific work and experience with follow-ups in thousands of herpes patients
• The homogenous, well-structured content and index make it easy for the reader to find the necessary information rapidly
• The ‘evidence-based’ treatment recommendations help the reader to apply the most appropriate treatment strategy

This ‘cooking book’ - atlas for Herpetic Eye Disease supports the reader to find a better understanding for this eye disease. The content of this atlas is based on nearly four decades of practical and scientific work and experience with follow-ups in thousands of herpes patients.

Depending on one’s individual state of knowledge in this field one may find the solution by quickly checking the pictures and comparing it with the actual patient’s picture. The picture-associated text guides the reader with its headings Description, Pathophysiology, Differential Diagnosis, Therapeutic Principles to the most appropriate management of and best possible treatment outcome for these patients.

Thus, the homogenous and well-structured content and index make it easy for the reader to find the necessary information rapidly and will not only supports beginners but also experts in the field of ophthalmology.

Written for: Ophthalmologists and all other physicians dealing treating patients with herpetic eye disease

Keywords:

• Anterior Segment
• Eye Disease
• Herpes Simplex
• Keratoplasty
• Varizella zoster virus

Contents:

1 Common Characteristics and Distinct Features of Human Pathogenic Herpesviruses
Hartmut Hengel

1.1 Hallmarks of Herpesvirus Infections
1.2 Virus Taxonomy and Herpesviral Subfamilies
1.3 General Themes of Human Herpesvirus Infections
1.4 Distinct Features of Human Herpesviruses

2 Herpes Simplex Virus (HSV) Diseases of the Anterior Segment and the Adnexa 5
Rainer Sundmacher

2.1 Pathophysiology
2.2 Basics of Therapy
2.2.A Antiviral Agents for Superficial (Epithelial) Viral Disease
2.2.A.1 Trifluorothymidine (TFT) and Aciclovir (ACV)
2.2.A.2 Bromovinyldeoxyuridine (BVDU), a Potential Alternative
2.2.A.3 The Lasting Value of Mechanical Debridement
2.2.A.4 The Potential Value of Topical Interferon in Combination with Topical Antiviral Agents
2.2.B Antiviral Agents Plus Steroids for Deep Viral Disease
2.2.C Conservative Resurfacing Measures for Metaherpetic Superficial (Epithelial) Disease
2.2.D Surgical Reconstruction for Metaherpetic Deep Disease
2.3 HSV Blepharitis
2.4 HSV Conjunctivitis
2.5 Epithelial HSV Keratitis
2.6 Interstitial and Ulcerating HSV Keratitis
2.7 HSV Endotheliitis and Disciform Keratitis
2.8 HSV Trabeculitis and Acute Secondary Glaucoma
2.9 HSV Focal Serous Iritis
2.10 HSV Scleritis
2.11 Metaherpetic Corneal Disease
2.12 Clinically Manifest Primary HSV Infections
2.13 Herpes and Trauma
2.14 Intraocular Surgery and Keratoplasty in HSV Eyes
2.14.A General Rules for Surgery in Herpes Eyes
2.14.A.1 Systemic ACV Prophylaxis and Therapy of Herpes Complications
2.14.A.2 Cataract and Glaucoma Surgery
2.14.B Emergency Surgery with Different Tissue Covers
2.14.B.1 Conjunctiva
2.14.B.2 Cornea
2.14.B.3 Amnion
2.14.C Optical Improvement of an Irregular Corneal Surface
2.14.C.1 Contact Lenses
2.14.C.2 Excimer Laser
2.14.D Perforating Keratoplasty
2.14.D.1 Rotational Autokeratoplasty
2.14.D.2 Homokeratoplasty
2.14.D.2.1 Dry Eye Complications
2.14.D.2.2 Immune Reactions
2.14.D.2.3 HSV Recurrences
2.14.D.2.4 Secondary Glaucoma
2.14.D.2.5 Irritating Sutures
2.14.E Special Problem: Amebic Keratitis
2.15 Prophylaxis of HSV Recurrences

3 Varicella Zoster Virus (VZV) Diseases of the Anterior Segment and the Adnexes
Rainer Sundmacher

3.1 Zoster Pathophysiology and Therapy
Pathophysiology
Therapy
3.2 Ocular Disease in the Course of Primary VZV Infection (Varicella)
3.3 Zoster Blepharitis, Conjunctivitis, and General VZV Dissemination
3.4 Epithelial Zoster Keratitis
3.5 Interstitial Zoster Keratitis and Endotheliitis
Addendum
3.6 Zoster Iritis
3.7 Zoster Scleritis
3.8 Late Corneal Complications After Zoster
3.9 Keratoplasty in Zoster Eyes
3.10 Differences Between VZV and HSV Ocular Disease

4 Cytomegalovirus (CMV) Diseases of the Anterior Segment
Rainer Sundmacher and Johannes Stammen

5 Suspected Epstein–Barr Virus (EBV) Disease of the Anterior Segment
Thomas Reinhard

5.1 General Pathophysiology and Epidemiology
5.2 Laboratory Diagnosis
5.3 Ocular Manifestations
5.4 Therapy of Recurrent EBV Disease of the Eye

6 Diseases of the Posterior Segment by HSV, VZV, and CMV
Lutz L. Hansen

6.1 Epidemiology and Pathogenesis
6.2 Phenotypic Clinical Features
6.2.1 Herpetic Retinitis
6.2.2 Acute Retinal Necrosis (ARN)
6.2.3 Progressive Outer Retinal Necrosis (PORN)
6.3 Virus Specific Features
6.3.1 Herpes Simplex Virus (HSV)
6.3.2 Varicella Zoster Virus (VZV)
6.3.3 Cytomegalovirus (CMV)
6.3.4 Epstein–Barr Virus (EBV)
6.4 Diagnosis and Differential Diagnosis
6.5 Therapy .
6.5.1 General Guidelines
6.5.2 Herpetic Retinitis
6.5.3 Cytomegalovirus Retinitis
6.5.4 Acute Retinal Necrosis
6.5.5 Progressive Outer Retinal Necrosis
6.5.6 Retinal Detachment

Subject Index