Long-Lived Proteins in Human Aging and Disease

Dedication


Foreword


Series editor's preface


Preface


01 Long-lived cells and long-lived proteins in the human body


02 Imaging Mass Spectrometry of Long-Lived Proteins


03 Eye lens crystallins: remarkable long-lived proteins


04 Spontaneous breakdown of long-lived proteins in aging and their implications in disease


05 Modifications of Long-lived Proteins that affect Protein Solubility


06 Degradation of Long-lived proteins as a cause of Autoimmune diseases


07 How Isomerization and Epimerization in Long-lived Proteins Affects Lysosomal Degradation and Proteostasis


08 The Maillard Reaction. Protein Modification by Ascorbic Acid

This comprehensive overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins and their role in age-related diseases and in determining human lifespan.

Roger Truscott is a Research Professor at the Illawarra Health and Medical Research Institute, University of Wollongong. Having obtained his PhD at Melbourne University, he has spent most of his academic career working for the University of Sydney and the University of Wollongong. He has authored over 200 scientific publications. His main field of research is human aging with particular reference to age-related diseases, such as cataract. He has received numerous awards including a senior NHMRC fellowship and the National Foundation for Eye Research (USA) Cataract Research Award.