Opening with a general introduction on chemokine function and chemokine receptor biology, the handbook goes on to cover the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including HIV/AIDS. The second half of the book systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners. Contributions in the first part of the book are mainly from academia, whereas the second part contains up-to-date reports from the pharmaceutical industry.
Table of Contents
FUNDAMENTALS OF CHEMOKINES AND CHEMOKINE RECEPTORS.
- Structural Aspects of Chemokines, and their Interactionss with Receptors and GAGs.
- Structural Insights for Homology Modeling of Chemokine Receptors.
- Signaling Events Involved in Chemokine-Directed T Lymphocyte Migration.
- The Atypical Chemokine Receptors.
- Targeting Chemokine Receptor Dimers: Are there Two (or More) to Tango?
CHEMOKINE RECEPTORS IN DISEASE.
- Chemokine Receptors in Inlammatory Diseases.
- Chemokines and their Receptors in Central Nervous System Disease.
- Chemokines and Cancer Metastasis.
- Constitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and Pathogenesis.
TARGETING CHEMOKINE RECEPTORS.
- CCR5 Antagonists in HIV.
- CXCR4 as therapeutic target.
- Low-Molecular Weight CXCR2 Antagonists as Promising Therapeutics.
- Therapeutic Targeting of the CXCR3 Receptors
- Targeting CCR3.
- Chemokine-Binding Proteins as Therapeutics.
The editors are based at the Amsterdam Center for Drug Research, a cross-disciplinary center in the Dutch academic system, but with numerous ties to pharmaceutical companies.