Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled
here the combined efforts of several scientific disciplines into a uniform picture
of the largest enzyme complex found in living cells, finally resolving many
decades-old questions in molecular biology.
In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.
Table of contents
1. History of Protein Biosynthesis and Ribosome Research (H.-J. Rheinberger).
2. Structure of the Ribosome (G. Blaha).
3. Ribosome Assembly (K. H. Nierhaus).
4. tRNA and Synthetases (V. Marquéz & K. Nierhaus).
5. mRNA Decay and RNA-degrading Machines in Prokaryotes and Eukaryotes (A. J. Carpousis and M. Dreyfus).
6. tRNA Locations on the Ribosome (K. Nierhaus).
7. Initiation of Protein Synthesis (D. Wilson).
8. The Elongation Cycle (K. H. Nierhaus).
9. Termination and Ribosome Recycling (D. Wilson).
10. The Mechanism of Recoding in Pro- and Eukaryotes (E. S. Poole, et al.).
11. Regulation of Ribosome Biosynthesis in Escherichia Coli (M. Iskakova, et al.).
12. Antibiotics and the Inhibition of Ribosome Function (D. Wilson).
13. The Work of Chaperones (J. Alix ).