This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach.
Table of Contents
Introduction to Pharmacogenomics: Promises, Opportunities, and Limitations
The Human Genome
Turning SNPs into Useful Markers of Drug Response
Association Studies in Pharmacogenomics
Genomics Applications that Facilitate the Understanding of Drug Action and Toxicity
The Role of Pharmacogenomics in Drug Discovery and Therapeutics
Pharmacogenomics and Drug Design
The Pharmacogenomics of Human P-glycoprotein
Pharmacogenomics of Drug Transporters
Pharmacogenomics of Asthma Treatment
Endothelial Cells are Targets for Hydroxy Urea: Relevance to the Current Therapeutic Strategy in Sickle Cell Disease
Pharmacogenomics and Complex Cardiovascular Disease -
Clinical Studies in Candidate Genes
Pharmacogenomics of Lipid-lowering Agents
Pharmacogenomics of Chemotherapeutic Agents in Cancer Treatment
Pharmacogenomics of the Blood-Brain Barrier
Pharmacogenomics and the Treatment of Neurological Disease
Pharmacogenomics of Neurodegenerative Diseases: Examples and Perspectives
Psychiatric Pharmacogenomics: Prediction of Treatment Outcomes in Schizophrenia
Pharmacogenomics of Major Depression and Antidepressant Treatment
Pharmacogenomics of Bipolar Disorder
Pharmacogenomics of Alcoholism
Pharmacogenomics of Tobacco Addiction
Pharmacogenomics of Opioid Systems
Ethnicity and Pharmacogenomics
Pharmacogenomics: Ensuring Equity Regarding Drugs Based on Genetic Difference
Translation of Vascular Proteomics into Individualized Therapeutics
Glossary of Key Terms in Molecu-lar Genetics of Pharmacogeno-mics
... the book does an excellent job of compiling a current picture of an important
and compelling field of medical research.
Ronald Norton, VP, Operations DNA Sciences
... a very successful approach to cover the emerging discipline of pharmacogenomics
from definitions to applications including ethical issues.
This book offers a wealth of highly actual information and can be emphatically recommended not only for those already working in pharmacogenomics but also for newcomers and life scientists who may intend to include pharmacogenomics in their research or teaching.
Matthias U Kassak, University of Bonn, Germany, European Journal of Pharmaceutics and Biopharmaceutics
... Licinio and Wong have done an exellent job in bringing together a diverse
assortment of views by leading experts in the field...
It is a timely and comprehensive book on the subject, and I recommend that it be essential reading for practioners.
The style used is easy to read - story-like and informative...
In conclusion, this is an excellent book that I recommend to be worth reading by all those in the field. I also has value as an important reference source.
Kosta Steliou, Boston, Ma (USA), ChemBioChem