Part I: Causes of Chimerism in Humans
Chapter 1: Fertilization and Early Embryonic ErrorsNicole L. Draper, Kristy Crooks
Chapter 2: Pregnancy and Multiple GestationsLinda Marie Randolph, Ramen H. Chmait
Chapter 3: Transplantation and TransfusionJoel N. Kniep
Part II: Clinical Identification and Consequences of Chimerism
Chapter 4: Relationship Testing and Forensics Kayla Sheets, Robert Wenk
Chapter 5: Prenatal Genetic Testing and ScreeningIgnatia B. Van den Veyver
Chapter 6: Blood Typing DiscrepanciesOpal L. Reddy, Dawn C. Ward, Andrea M. McGonigle
Chapter 7: Hematopoietic Stem Cell Donor Selection and Graft-Versus-Host DiseaseAlexa J. Siddon, Christopher A. Tormey
Chapter 8: Passenger Lymphocyte SyndromeNicole L. Draper, Jamie E. Kallan
Chapter 9: Chimerism: A Clinical Guide to Tolerance InductionAndrea R. Merchak, Anita Chhabra, Joseph Leventhal, Suzanne T. Ildstad
Chapter 10: Autoimmune DiseaseNathalie Lambert
Chapter 11: CancerValentina Cirello, Laura Fugazzola
This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome. Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented.
Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.
Nicole L. Draper, MD University of Colorado School of Medicine. Department of Pathology. Aurora, CO USA