Role of Genetics and Epigenetics in neurodegenerative disorders of the central nervous system.- Diagnosis and treatment of Alzheimer's Disease and atypical forms.- Autosomal Dominant Alzheimer's Disease: Underlying Causes.- Genetic Risk Factors for sporadic Alzheimer's Disease.- The Role of Cerebrovascular Disease in Cognitive Decline.- Environmental Risk Factors in Alzheimer's Disease and Mild Cognitive Impairment.- Diagnosis of Frontotemporal dementia.- Autosomal dominant Frontotemporal Lobar Degeneration: from genotype to phenotype.- Genetic Risk Factors for sporadic Frontotemporal Dementia.- Alzheimer's Disease and Frontotemporal Lobar Degeneration: Mouse Models.- Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Frontotemporal Dementia.- Biomarkers for Alzheimer's Disease and Frontotemporal Lobar Degeneration: Imaging.- Amyotrophic Lateral Sclerosis: Genotypes and Phenotypes.- Lewy Body dementia.- Rare Dementias.- Neurodevelopment Alterations, Neurodegeneration, and Immunoinflammatory Patterns in the Pathophysiology of Schizophrenia and bipolar disorders.- Parkinson's disease.- Neurodegeneration and Multiple Sclerosis.
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson's disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Dr. Galimberti is the Secretary of the Dementia Panel of the European Academy of Neurology and the Italian Society for the research on dementia (Sindem).She is author of more than 250 scientific articles in international peer-reviewed journals, 10 chapters in international volumes, and more than 350 contributions to conferences. She serves as reviewer for several neurological journals. She is a Senior Associate Editor of the "Journal of Alzheimer's disease".
Elio Scarpini got his degree in Neurology in 1981 and he is professor of Neurology at the University of Milan. He is the Chief of the Alzheimer Center at the Policlinico University Hospital (Milan, Italy). His main interests include clinical and therapeutic aspects of neurodegenerative disorders (Alzheimer's disease, Frontotemporal Lobar Degeneration) and demyelinating diseases (Multiple Sclerosis). He is author of more than 300 scientific articles in international peer-reviewed journals and serves as reviewer for several neurological journals.