Part I: General Aspects.- Introduction: Definition and classification of hypertension phenotypes.- Predictors, clinical and prognostic significance of BP indices [peripheral/central (systolic, diastolic, mean and pulse pressures)].- Role of circadian rhythms and seasonal variation in BP levels.- Natural history of untreated and treated hypertension.- Part II: Mechanisms of hypertension development.- Hemodynamics.- Neurohormonal systems.- Vasoactive substances.- Endothelial function.- Genetics of hypertension.- Part III: Hypertension Phenotypes (Clinical manifestation, course mechanism, prognosis and management).- Monogenic Forms of Hypertension.- Turner Syndrome.- Part IV: The Heart and Hypertension.- Hypertensive heart disease.- Postoperative cardiac surgery hypertension.- Nonsynchronic supravalvular aortic stenosis.- Coarctation of the aorta.- Atrial fibrillation and hypertension.- Part V: Role of neurogenic factors in hypertension.- Sleep disturbances, sleep apnea.- Stress and hypertension.- CNS ischemic disorders (Transient Ischemic attacks, Stroke ischemic/hemorrhagic).- Part VI: The Kidney and Hypertension.- Chronic kidney disease.- Calculus renal disease.- Hyperuricemic hypertension.- Dialysis Hypertension.- Renovascular Hypertension (Fibromuscular dysplasia, Ischemic nephropathy).- Molecular pathways in hypertensive renal damage.- Determinants of BP related decline in hypertensive renal disease.- Part VII: Endocrine causes of hypertension.- Cushing Syndrome and hypercorticism.- Primary aldosteronism and its various scenarios.- Pheochromocytoma.- Disorders in thyroid function (Hypothyroidism).- Hyperparathyroidism.- Part VIII: Special types of hypertension.- Prehypertension.- White coat and masked hypertension.- Isolated systolic hypertension (In the young, In the elderly).- Resistant hypertension.- Accelerated / malignant hypertension.- Nocturnal hypertension.- Salt and hypertension: Salt sensitive and salt resistant forms of hypertension.- Diabetes mellitus and Hypertension.- Obesity and metabolic syndrome Hypertension.- Herbal and medicinal compounds and pharmacologic agents.- Part IX: Hypertensive disorders of pregnancy and Pediatric Hypertension.- Gestational hypertension / Preeclampsia / Toxemia of pregnancy.- Blood Pressure trends in children and adolescents / Predictors of BP elevation in children and adolescents.- Hypertension in children and adolescents.- Part X: Management / Therapeutic approaches.- Summary of guidelines for blood pressure control.- Novel antihypertensive agents.- Place of invasive procedures in blood pressure control.- Are hypertension-related target organ involvement/damage reversible/ preventable?
This book aims to present a comprehensive classification of hypertensive phenotypes based on underlying target organ involvement. Particular emphasis is placed on review and assessment of clinical presentation, pathophysiologic mechanisms, and possible specific therapeutic options for each hypertension phenotype. Several of these phenotypes are well known and well described in the literature, such as prehypertension, white coat and masked hypertension, isolated systolic hypertension, renovascular hypertension, endocrine hypertension, pediatric hypertension, and gestational hypertension. Other hypertension phenotypes, however, are not widely recognized, being reported only in special reviews; examples include hypertension associated with renal calculus disease and other rarer causes such as Turner syndrome, herbal and medicinal compounds, and pharmacologic agents. A detailed account of the various causes of monogenic hypertension is also included. Finally, a section is devoted to general aspects of hypertension, including the significance of blood pressure indices, the natural course of untreated and treated hypertension, hypertension mechanisms, genetics, and guidelines for blood pressure control.