- The first book to target current research on adamantinomatous craniopharyngiomas (ACPs)
- Topics covered range from pathogenesis to clinical diagnosis to long-term management
- Includes novel and effective treatment approaches
This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascularstructures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detailadvances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches.
Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology ofthe majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adultpituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have beenshown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
Dr Juan Pedro Martinez-Barbera, is a leading expert in pituitary development, is a researchers at the Birth Defects Research Centre, Developmental Biology and Cancer Programme of the UCL Institute of Child Health.
Dr. Cynthia Lilian Andoniadou is a researcher at the Department of Craniofacial Development and Stem Cell Biology of King’s College London.